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Literature DB >> 6168587

Hypoglycemia in mice injected with interferon inducers is not mediated by interferon.

Abstract

Injection of mice with several viral and nonviral inducers of interferon resulted in a marked hypoglycemia. Interferon is not responsible for this effect since inoculation of a potent antiserum to interferon (which neutralized the endogenous interferon) did not prevent hypoglycemia and administration of potent interferon preparations did not lower blood sugar. Hypoglycemia induced by Newcastle disease virus and polyriboinosinic-polyribocytidylic acid was further exacerbated by injection of insulin.

Entities: Chemical Disease Species

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Year: 1981 PMID： 6168587 PMCID： PMC350702 DOI： 10.1128/iai.33.2.331-337.1981

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

38 in total

1. Lethality of interferon preparations for newborn mice.

Authors: I Gresser; M G Tovey; C Maury; I Chouroulinkov
Journal: Nature Date: 1975-11-06 Impact factor: 49.962

2. In vivo vs in vitro effects of endotoxin on glycogenolysis, gluconeogenesis, and glucose utlization.

Authors: J P Filkins; B J Buchanan
Journal: Proc Soc Exp Biol Med Date: 1977-06

3. Studies on poly I:C toxicity in experimental animals.

Authors: E R Homan; R P Zendzian; L D Schott; H B Levy; R H Adamson
Journal: Toxicol Appl Pharmacol Date: 1972-12 Impact factor: 4.219

4. Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis.

Authors: J S Youngner; W R Stinebring
Journal: Nature Date: 1965-10-30 Impact factor: 49.962

10. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection.

Authors: I Gresser; M G Tovey; M E Bandu; C Maury; D Brouty-Boyé
Journal: J Exp Med Date: 1976-11-02 Impact factor: 14.307

1 in total

1. Induction of hypoglycaemia and accumulation of 5-hydroxytryptamine in the liver after the injection of mitogenic substances into mice.

Authors: Y Endo
Journal: Br J Pharmacol Date: 1984-04 Impact factor: 8.739

1 in total

Hypoglycemia in mice injected with interferon inducers is not mediated by interferon.

1. Lethality of interferon preparations for newborn mice.

2. In vivo vs in vitro effects of endotoxin on glycogenolysis, gluconeogenesis, and glucose utlization.

3. Studies on poly I:C toxicity in experimental animals.

4. Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis.

5. Toxicity of interferon inducers of the double stranded RNA type.

6. Pyrogenicity of poly I. poly C in rabbits.

7. Embryotoxic effect of poly I. poly C.

8. Partial purification of a serum factor that causes necrosis of tumors.

9. Study of inhibition of induction of phosphoenolpyruvate carboxykinase by endotoxin with radial immunodiffusion.

10. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection.

1. Induction of hypoglycaemia and accumulation of 5-hydroxytryptamine in the liver after the injection of mitogenic substances into mice.