Literature DB >> 580369

The influence of unithiol and spironolactone on the biliary excretion of 203Hg in rat.

M Cikrt.   

Abstract

Rats with cannulated bile ducts were intravenously given 203HgCl2 in the dose of 120 microgram of Hg2+ per rat. Intramuscular administration of Unithiol (sodium 2,3-dimercaptopropanosulphonate) 4 and 7 h after 203Hg injection markedly increased both biliary and urinary excretion of 203Hg. In rats with Spironolactone (17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone, acetate) pretreatment the effect of Unithiol on the biliary excretion of 203Hg was enhanced. Urinary excretion of mercury was lowest in comparison with Unithiol treated group.

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Year:  1978        PMID： 580369     DOI： 10.1007/bf00368230

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  7 in total

1.  Effect of spironolactone on the distribution of mercury.

Authors:  C D Klaassen
Journal:  Toxicol Appl Pharmacol       Date:  1975-08       Impact factor: 4.219

2.  The influence of spironolactone on the excretion of 203Hg2+ in rats.

Authors:  M Cikrt; M Tichý
Journal:  Environ Res       Date:  1975-12       Impact factor: 6.498

3.  Biliary excretion of mercury enhanced by spironolactone.

Authors:  J E Haddow; C A Fish; P C Marshall; R Lester
Journal:  Gastroenterology       Date:  1972-12       Impact factor: 22.682

4.  Increased stool mercury excretion in the rat: the effect of spironolactone.

Authors:  J E Haddow; P Marshall
Journal:  Proc Soc Exp Biol Med       Date:  1972-06

5.  Effect of spironolactone on the distribution and excretion of 203-HgCl2 in the rat.

Authors:  B D Garg; B Solymoss; B Tuchweber
Journal:  Arzneimittelforschung       Date:  1971-06

6.  Mercury poisoning: prevention by spironolactone.

Authors:  H Selye
Journal:  Science       Date:  1970-08-21       Impact factor: 47.728

7.  [Effect of unithiol on the bile excretion of mercury in rats].

Authors:  M Cikrt; M Tichý; A S Ivanova; V I Fedorova
Journal:  Gig Tr Prof Zabol       Date:  1978-10
  7 in total
  1 in total

1.  Chelation in metal intoxication XXVI : Influence of thiamine on the therapeutic efficacy of calcium disodium edetate in lead intoxication.

Authors:  D N Kachru; S Khandelwal; S K Tandon
Journal:  Biol Trace Elem Res       Date:  1987-10       Impact factor: 3.738
  1 in total

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