Literature DB >> 1250243

Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor.

S Osterman-Golkar, L Ehrenberg, D Segerbäck, I Hällström.   

Abstract

The degree of alkylation of haemoglobin was determined at different times after treatment of mice with one directly active alkylating agent, ethylene oxide, and one agent that requires metabolic activation, dimethylnitrosamine. Because of the random alkylation of red blood cells of various ages and the stability of alkylated haemoglobin, the amount of alkylated amino acids in haemoglobin decreases linearly with time, reaching the value zero after about 40 days, the life-span of erythrocytes in the mouse. This provides a basis for the use of haemoglobin as a monitor for integral doses of genotoxic environmental chemicals.

Entities:  

Mesh：

Substances：

Year:  1976        PMID： 1250243     DOI： 10.1016/0027-5107(76)90256-6

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  39 in total

Review 1.  Protein damage by reactive electrophiles: targets and consequences.

Authors:  Daniel C Liebler
Journal:  Chem Res Toxicol       Date:  2007-12-04       Impact factor: 3.739

Review 2.  The use of biomonitoring data in exposure and human health risk assessment: benzene case study.

Authors:  Scott M Arnold; Juergen Angerer; Peter J Boogaard; Michael F Hughes; Raegan B O'Lone; Steven H Robison; A Robert Schnatter
Journal:  Crit Rev Toxicol       Date:  2013-02       Impact factor: 5.635

Review 3.  Estimation of exposure of man to substances reacting covalently with macromolecules.

Authors:  P B Farmer; H G Neumann; D Henschler
Journal:  Arch Toxicol       Date:  1987-06       Impact factor: 5.153

4.  GC/MS determination of N-phenylvaline, a possible biomarker for benzene exposure in human hemoglobin by the "N-alkyl Edman method".

Authors:  M Bader; G Lehnert; J Angerer
Journal:  Int Arch Occup Environ Health       Date:  1994       Impact factor: 3.015

5.  Metabolic activation of diethylstilbestrol and aminostilbene-derivatives.

Authors:  H G Neumann; M Metzler; W Töpner
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

6.  Estimation of exposure to alkylating carcinogens by the GC-MS determination of adducts to hemoglobin and nucleic acid bases in urine.

Authors:  E Bailey; P B Farmer; D E Shuker
Journal:  Arch Toxicol       Date:  1987       Impact factor: 5.153

7.  Blood protein conjugates and acetylation of aromatic amines. New findings on biological monitoring.

Authors:  J Lewalter; U Korallus
Journal:  Int Arch Occup Environ Health       Date:  1985       Impact factor: 3.015

8.  Hydroxyethylvaline adduct formation in haemoglobin as a biological monitor of cigarette smoke intake.

Authors:  E Bailey; A G Brooks; C T Dollery; P B Farmer; B J Passingham; M A Sleightholm; D W Yates
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

9.  Methemoglobin formation and binding to blood constituents as indicators for the formation, availability and reactivity of activated metabolites derived from trans-4-aminostilbene and related aromatic amines.

Authors:  E Wieland; H G Neumann
Journal:  Arch Toxicol       Date:  1978-02-21       Impact factor: 5.153

10.  LC/MS/MS Analysis of N-Terminal Protein Adducts with Improved Sensitivity: A Comparison of Selected Edman Isothiocyanate Reagents.

Authors:  Per Rydberg; Hans von Stedingk; Jörgen Magnér; Jonas Björklund
Journal:  Int J Anal Chem       Date:  2009-11-04       Impact factor: 1.885
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.