Literature DB >> 5798313

Ascorbic acid: cofactor in rabbit olfactory preparations.

K O Ash.   

Abstract

A stimulant-induced decrease in absorbance at 267 nanometers in preparations from rabbit olfactory epithelium requires ascorbic acid as a cofactor. Vitamin C is bound to proteins in the olfactory mucosa in vivo. When the stimulant. 3,7-dimethyl-6-octen-3-ol interacts with olfactory proteins, it triggers a change in protein conformation which renders ascorbic acid available for oxidation. The specific decrease in absorbance at 267 nanometers is produced when the "freed" ascorbic acid is oxidized.

Entities:  

Mesh:

Substances:

Year:  1969        PMID: 5798313     DOI: 10.1126/science.165.3896.901

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  3 in total

1.  A hypothesized unifying mechanism in neural function.

Authors:  D M Norris
Journal:  Experientia       Date:  1971-05-15

2.  Proceedings: The relationship of ascorbic acid to leptazol-induced convulsions in guinea-pigs.

Authors:  A Odumosu; C W Wilson
Journal:  Br J Pharmacol       Date:  1974-03       Impact factor: 8.739

3.  Biochemical studies of olfaction: binding specificity of radioactively labeled stimuli to an isolated olfactory preparation from rainbow trout (Salmo gairdneri).

Authors:  R H Cagan; W N Zeiger
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.