Literature DB >> 579561

Pharmacokinetics of trimethoprim (TMP) in normal and febrile rabbits.

O Ladefoged.   

Abstract

The pharmacokinetics of trimethoprim (TMP) were investigated in normal and febrile rabbits. The half-life of TMP in rabbits is about 40 minutes and no differences were found between the half-life in normal and febrile rabbits. A significantly greater volume of distribution of TMP, however, was found in the febrile rabbits. Analysis according to the two-compartment model showed that the differences are due to a change in the distribution of TMP towards the peripheral compartments.

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Year:  1977        PMID： 579561     DOI： 10.1111/j.1600-0773.1977.tb02162.x

Source DB:  PubMed          Journal:  Acta Pharmacol Toxicol (Copenh)        ISSN： 0001-6683


  5 in total

1.  Disposition kinetics of erythromycin in normal and experimentally-induced febrile rabbits.

Authors:  M Ahmad; T Ahmad; N I Bukhari
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1999 Apr-Jun       Impact factor: 2.441

2.  Bioavailability and pharmacokinetics of sulphadiazine, N4-acetylsulphadiazine and trimethoprim following intravenous and intramuscular administration of a sulphadiazine/trimethoprim combination in sheep.

Authors:  G C Batzias; G A Delis; M Koutsoviti-Papadopoulou
Journal:  Vet Res Commun       Date:  2005-11       Impact factor: 2.459

3.  Granulocyte colony-stimulating factor enhances endotoxin-induced decrease in biliary excretion of the antibiotic cefoperazone in rats.

Authors:  M Nadai; I Matsuda; L Wang; A Itoh; K Naruhashi; T Nabeshima; M Asai; T Hasegawa
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

4.  The effect of tick-borne fever on metabolism and renal clearance of sulfadimidine in goats.

Authors:  J F Nouws; A S Van Miert; H Van Gogh; A D Watson; T B Vree
Journal:  Pharm Weekbl Sci       Date:  1987-04-24

5.  Changes of pharmacokinetics of trimethoprim after pretreatment with streptococcal peptidoglycan.

Authors:  J Lavický; J Cerný; L Celeda; J Rotta; J Kvĕtina; H Raśková; A Kubícek
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1986 Jan-Mar       Impact factor: 2.441
  5 in total

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