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Literature DB >> 3720793

Changes of pharmacokinetics of trimethoprim after pretreatment with streptococcal peptidoglycan.

J Lavický, J Cerný, L Celeda, J Rotta, J Kvĕtina, H Raśková, A Kubícek.

Abstract

Trimethoprim (TMP) 10 mg.kg-1 was given orally to calves and rabbits. Two to three weeks later the animals were pretreated by i.v. Peptidoglycan (Pt) 20 micrograms.kg-1. One hour later TMP was administered as above. To other animals under otherwise identical conditions TMP was injected intravenously. The pretreatment with Peptidoglycan induced in both species a significant increase of TMP serum levels positively correlated with temperature elevation. Peptidoglycan pretreatment increased the bioavailability of TMP.

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Year: 1986 PMID： 3720793 DOI： 10.1007/BF03189770

Source DB: PubMed Journal: Eur J Drug Metab Pharmacokinet ISSN： 0378-7966 Impact factor: 2.441

15 in total

10. Studies on the chemical structure of the streptococcal cell wall. I. The identification of a mucopeptide in the cell walls of groups A and A-variant streptococci.

Authors: R M KRAUSE; M MCCARTY
Journal: J Exp Med Date: 1961-07-01 Impact factor: 14.307

1 in total

1. Increased oral bioavailability of ciprofloxacin in cystic fibrosis patients.

Authors: B A Christensson; I Nilsson-Ehle; B Ljungberg; A Lindblad; A S Malmborg; L Hjelte; B Strandvik
Journal: Antimicrob Agents Chemother Date: 1992-11 Impact factor: 5.191

1 in total

Changes of pharmacokinetics of trimethoprim after pretreatment with streptococcal peptidoglycan.

1. Biological properties of the peptidoglycan.

2. Pharmacokinetics of sulfadimidine in normal and diarrheic calves.

3. Pyrogenic activity of bacterial mucopeptides.

4. On the mechanism of fever caused by the mucopeptide of group A streptococcus.

5. The influence of pyrogen induced fever on absorption of sulpha drugs.

6. [The effect of endotoxins on the level of rifampicin in the blood of calves].

7. Pharmacokinetics of trimethoprim (TMP) in normal and febrile rabbits.

8. Ontogenic drug studies in calves. II. Changes in salicylate levels and metabolism in calves with diarrhoea.

9. The mechanism of the pyrogenic effect of streptococcus cell wall mucopeptide.

10. Studies on the chemical structure of the streptococcal cell wall. I. The identification of a mucopeptide in the cell walls of groups A and A-variant streptococci.

1. Increased oral bioavailability of ciprofloxacin in cystic fibrosis patients.