Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Genetic control of drug levels in man: phenylbutazone.

Literature DB >> 5753556

Genetic control of drug levels in man: phenylbutazone.

Abstract

Phenylbutazone was administered to seven pairs of identical (monozygotic) twins and to seven pairs of fraternal (dizygotic) twins. Individual half-lives ranged from 1.2 to 7.3 days. Subjects with identical genotypes (monozygotic twins) exhibited very similar phenylbutazone half-lives; significantly greater differences in half-life occurred in dizygotic twins. The previously established large variations among individuals in phenylbutazone metabolism appear to be genetically, rather than environmentally, determined.

Entities: Chemical Species

Mesh：

Substances：
Phenylbutazone

Year: 1968 PMID： 5753556 DOI： 10.1126/science.159.3822.1479

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

Keyword Cloud
Cited

33 in total

Review 1. Pharmacogenomics: challenges and opportunities.

Authors: Dan M Roden; Russ B Altman; Neal L Benowitz; David A Flockhart; Kathleen M Giacomini; Julie A Johnson; Ronald M Krauss; Howard L McLeod; Mark J Ratain; Mary V Relling; Huijun Z Ring; Alan R Shuldiner; Richard M Weinshilboum; Scott T Weiss
Journal: Ann Intern Med Date: 2006-11-21 Impact factor: 25.391

2. Pharmacogenetics, pharmacogenomics and ecogenetics.

Authors: Arno G Motulsky; Ming Qi
Journal: J Zhejiang Univ Sci B Date: 2006-02 Impact factor: 3.066

3. Genomic medicine: a new frontier of medicine in the twenty first century.

Authors: Dhavendra Kumar
Journal: Genomic Med Date: 2007-04-24

4. Salivary gland reaction to phenylbutazone.

Authors: S Mirsky
Journal: Can Med Assoc J Date: 1970-01-17 Impact factor: 8.262

Review 5. Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity.

Authors: Volker M Lauschke; Yitian Zhou; Magnus Ingelman-Sundberg
Journal: Pharmacol Ther Date: 2019-01-22 Impact factor: 12.310

6. Influence of allopurinol on drug metabolism in man.

Authors: M D Rawlins; S E Smith
Journal: Br J Pharmacol Date: 1973-08 Impact factor: 8.739

7. Risk assessment and communication tools for genotype associations with multifactorial phenotypes: the concept of "edge effect" and cultivating an ethical bridge between omics innovations and society.

Authors: Vural Ozdemir; Guilherme Suarez-Kurtz; Raphaëlle Stenne; Andrew A Somogyi; Toshiyuki Someya; S Oğuz Kayaalp; Eugene Kolker
Journal: OMICS Date: 2009-02