Literature DB >> 571145

Thiourea reverses cross-links and restores biological activity in DNA treated with dichlorodiaminoplatinum (II).

J Filipski, K W Kohn, R Prather, W M Bonner.   

Abstract

Cis and trans dichlorodiaminoplatinum (II) compounds bind to DNA and form DNA cross-links, which are usually considered to be irreversible. Thiourea can reverse these cross-links without any apparent breakdown of the DNA. In addition, cis- and trans-Pt (II) treatment of lambda decreases its transfectivity. After suitable incubation with thiourea, full transfectivity of Pt(II)-treated lambda DNA can be restored.

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Year:  1979        PMID： 571145     DOI： 10.1126/science.571145

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

1.  Chromosome-protein interactions in polyomavirus virions.

Authors:  Mariarosaria Carbone; Giuseppe Ascione; Silvia Chichiarelli; Marie-Isabelle Garcia; Margherita Eufemi; Paolo Amati
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

2.  Determination of cis-diamminedichloroplatinum (II) in plasma proteins and hemoglobin of cancer patients.

Authors:  R Mustonen; P Hietanen; S Leppälä; M Takala; K Hemminki
Journal:  Arch Toxicol       Date:  1989       Impact factor: 5.153

3.  Protection of antiproliferative effect of cis-diamminedichloroplatinum (II) by sodium thiosulfate.

Authors:  R Abe; T Akiyoshi; H Tsuji; T Baba
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

4.  Inhibition of cis-platinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model.

Authors:  R F Borch; M E Pleasants
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

5.  Repair of cis-platinum-DNA adducts by ABC excinuclease in vivo and in vitro.

Authors:  I Husain; S G Chaney; A Sancar
Journal:  J Bacteriol       Date:  1985-09       Impact factor: 3.490

6.  Binding of cis- and trans-dichlorodiammineplatinum(II) to the nucleosome core.

Authors:  S J Lippard; J D Hoeschele
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

7.  Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II).

Authors:  D J Beck; S Popoff; A Sancar; W D Rupp
Journal:  Nucleic Acids Res       Date:  1985-10-25       Impact factor: 16.971

8.  Association of cytokeratin p39 with DNA in intact Novikoff hepatoma cells.

Authors:  W S Ward; W N Schmidt; C A Schmidt; L S Hnilica
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

9.  Formation and stability of interstrand cross-links induced by cis- and trans-diamminedichloroplatinum (II) in the DNA of Saccharomyces cerevisiae strains differing in repair capacity.

Authors:  F Wilborn; M Brendel
Journal:  Curr Genet       Date:  1989-12       Impact factor: 3.886

10.  Use of exonuclease III to determine the site of stable lesions in defined sequences of DNA: the cyclobutane pyrimidine dimer and cis and trans dichlorodiammine platinum II examples.

Authors:  B Royer-Pokora; L K Gordon; W A Haseltine
Journal:  Nucleic Acids Res       Date:  1981-09-25       Impact factor: 16.971
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