Literature DB >> 570865

Prostaglandin D2 is the prevailing prostaglandin in the acute inflammatory exudate of urate arthritis in the chicken.

H Anhut, K Brune, J C Frölich, B A Peskar.   

Abstract

An acute inflammation was elicited in intertarsal joints of chicken by injection of urate crystals. Inflammatory exudates recovered at different times were assayed for prostaglandin D2(PGD2)E2 and F2 alpha and thromboxane B2 content by specific radioimmunoassays. We found that PGD2 was the prevailing prostaglandin reaching concentrations up to 10 times in excess of PGE2. This finding was confirmed by gas chromatography-mass spectrometry. It is concluded that PGD2 should be considered as a possible mediator of acute inflammation.

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Year:  1979        PMID： 570865      PMCID： PMC1668658          DOI： 10.1111/j.1476-5381.1979.tb07837.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  14 in total

1.  Leukocytes and prostaglandins in acute inflammation.

Authors:  M Glatt; B Peskar; K Brune
Journal:  Experientia       Date:  1974-11-15

2.  Prostaglandin D2 inhibits the aggregation of human platelets.

Authors:  J B Smith; M J Silver; C M Ingerman; J J Kocsis
Journal:  Thromb Res       Date:  1974-09       Impact factor: 3.944

3.  The avian microcrystal arthritis. 3. Invasion and enzyme-release from leukocytes at the site of inflammation.

Authors:  K Brune; M Glatt
Journal:  Agents Actions       Date:  1974-04

4.  Role of prostaglandin endoperoxide PGG2 in inflammatory processes.

Authors:  F A Kuehl; J L Humes; R W Egan; E A Ham; G C Beveridge; C G Van Arman
Journal:  Nature       Date:  1977-01-13       Impact factor: 49.962

5.  Radioimmunological determination of prostaglandin D2 synthesis in human thrombocytes.

Authors:  H Anhut; B A Peskar; W Wachter; B Gräbling; B M Peskar
Journal:  Experientia       Date:  1978-11-15

6.  Release of 15-keto-13, 14-dihydro-thromboxane B2 and prostaglandin D2 during anaphylaxis as measured by radioimmunoassay.

Authors:  H Anhut; B A Peskar; W Bernauer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-12       Impact factor: 3.000

7.  Identification of prostaglandin D2 as a major prostaglandin in homogenates of rat brain.

Authors:  M S Abdel-Halim; M Hamberg; B Sjöquist; E Anggård
Journal:  Prostaglandins       Date:  1977-10

8.  Prostaglandin d2 as a potential antithrombotic agent.

Authors:  E E Nishizawa; W L Miller; R R Gorman; G L Bundy; J Svensson; M Hamberg
Journal:  Prostaglandins       Date:  1975-01

9.  Effect of imidazole on prostaglandin and thromboxane accumulation in urate arthritis.

Authors:  B A Peskar; M Glatt; H Anhut; K Brune
Journal:  Eur J Pharmacol       Date:  1978-08-15       Impact factor: 4.432

10.  Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis.

Authors:  M Hamberg; B Samuelsson
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205
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  1 in total

1.  Evaluation of liposome-encapsulated butorphanol tartrate for alleviation of experimentally induced arthritic pain in green-cheeked conures (Pyrrhura molinae).

Authors:  Joanne R Paul-Murphy; Lisa A Krugner-Higby; Renee L Tourdot; Kurt K Sladky; Julia M Klauer; Nicholas S Keuler; Carolyn S Brown; Timothy D Heath
Journal:  Am J Vet Res       Date:  2009-10       Impact factor: 1.156
  1 in total

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