Literature DB >> 568970

In vitro effects of non-steroidal anti-inflammatory drugs on human polymorphonuclear cells and lymphocyte migration.

K A Brown, A J Collins.   

Abstract

1. The action of the non-steroidal anti-inflammatory drugs (NSAID), sodium salicylate, aspirin, phenylbutazone and indomethacin was investigated on the migration of human polymorphonuclear cells (PMNs) and lymphocytes, using the system of migration of leucocytes from glass capillary tubes. 2. All NSAID produced a dose-dependent inhibition of cell migration, and were more effective on the migration of the PMN than on lymphocytes. 3. Drugs optimally suppressed PMN migration after 20 to 24 h incubation, and lymphocytes after 3 to 6 h. 4. Prolonged incubation of cells with several concentrations of NSAID demonstrated an 'escape' from inhibition in PMNs prepared from one subject.

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Year:  1978        PMID： 568970      PMCID： PMC1668504     

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  16 in total

1.  Spontaneous lymphokine synthesis by human blood mononuclear cells.

Authors:  H Arvilommi; L Räsänen
Journal:  Nature       Date:  1975-09-11       Impact factor: 49.962

2.  Characterization of lactic dehydrogenase of normal human granulocytes.

Authors:  N DIOGUARDI; A AGOSTONI; G FIORELLI; B LOMANTO
Journal:  J Lab Clin Med       Date:  1963-05

3.  Action of nonsteroidal, anti-inflammatory drugs on human and rat peripheral leucocyte migration in vitro.

Authors:  K A Brown; A J Collins
Journal:  Ann Rheum Dis       Date:  1977-06       Impact factor: 19.103

4.  Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration.

Authors:  S C Meacock; E A Kitchen
Journal:  Agents Actions       Date:  1976-02

5.  'Escape' from leucocyte migration inhibition.

Authors:  J Brostoff
Journal:  J Immunol Methods       Date:  1974-01       Impact factor: 2.303

6.  Effect of phenylbutazone on phagocytosis and intracellular killing by guinea pig polymorphonuclear leukocytes.

Authors:  R R Strauss; B B Paul; A J Sbarra
Journal:  J Bacteriol       Date:  1968-12       Impact factor: 3.490

7.  Macrophage migration inhibition test: a critical examination of the technique using a polythene capillary tubing micromethod.

Authors:  D Hughes
Journal:  J Immunol Methods       Date:  1972-08       Impact factor: 2.303

8.  Indomethacin: plasma concentrations and protein binding in man.

Authors:  E Hvidberg; H H Lausen; J A Jansen
Journal:  Eur J Clin Pharmacol       Date:  1972-03       Impact factor: 2.953

9.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors:  J R Vane
Journal:  Nat New Biol       Date:  1971-06-23

10.  The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material.

Authors:  J J BURNS; R K ROSE; T CHENKIN; A GOLDMAN; A SCHULERT; B B BRODIE
Journal:  J Pharmacol Exp Ther       Date:  1953-11       Impact factor: 4.030
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  2 in total

1.  The effects of some antirheumatic drugs on an in vitro model of human polymorphonuclear leucocyte chemokinesis.

Authors:  M J Smith; J R Walker
Journal:  Br J Pharmacol       Date:  1980-07       Impact factor: 8.739

2.  Neutrophil response to LIF: lack of glucocorticoid effect despite enhanced chemokinesis.

Authors:  D P Lurie; F DeLustro; E C LeRoy
Journal:  Inflammation       Date:  1983-03       Impact factor: 4.092
  2 in total

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