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Literature DB >> 301730

Action of nonsteroidal, anti-inflammatory drugs on human and rat peripheral leucocyte migration in vitro.

Abstract

Using an in vitro system of cell migration from glass capillary tubes, the nonsteroidal, anti-inflammatory agents sodium salicylate, aspirin, ibuprofen, phenylbutazone, and indomethacin were shown to inhibit the migration of human peripheral leucocytes in a dose-related manner. This drug action was not confined to one species, as shown by the modification of rat peripheral leucocyte motility by sodium salicylate and aspirin. The relevance of the human findings to the clinical effectiveness of these agents is discussed.

Entities: Chemical Species

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Year: 1977 PMID： 301730 PMCID： PMC1006672 DOI： 10.1136/ard.36.3.239

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

15 in total

1. In vitro cell migration as a model for delayed hypersensitivity.

Authors: M GEORGE; J H VAUGHAN
Journal: Proc Soc Exp Biol Med Date: 1962-11

2. The effect of aspirin on serum indomethacin.

Authors: G D Champion; H E Paulus; E Mongan; R Okun; C M Pearson
Journal: Clin Pharmacol Ther Date: 1972 Mar-Apr Impact factor: 6.875

3. Effect of some drugs on the chemotaxis of rabbit neutrophils in vitro.

Authors: J F Borel
Journal: Experientia Date: 1973-06-15

4. Prostaglandins, leucocytes and non-steroidal anti-inflammatory drugs.

Authors: M Di Rosa
Journal: Pol J Pharmacol Pharm Date: 1974 Jan-Apr

5. Studies on anti-inflammatory agents. XXV. Effects of anti-inflammatory agents on leucocyte emigration in carrageenin-peritonitis of rats.

Authors: M Nakanishi; K Goto
Journal: Yakugaku Zasshi Date: 1974-10 Impact factor: 0.302

6. Competition between salicylate and other drugs in binding to human serum protein in vitro.

Authors: K D Muirden; P Deutschman; M Phillips
Journal: Aust N Z J Med Date: 1974-04

7. Standardization of the leucocyte migration test.

Authors: R N Maini; L M Roffe; I T Magrath; D C Dumonde
Journal: Int Arch Allergy Appl Immunol Date: 1973

8. Hydrocortisone and the migration of human leucocytes: an indirect effect mediated by mononuclear cells.

Authors: R D Stevenson
Journal: Clin Exp Immunol Date: 1973-07 Impact factor: 4.330

9. Indomethacin: plasma concentrations and protein binding in man.

Authors: E Hvidberg; H H Lausen; J A Jansen
Journal: Eur J Clin Pharmacol Date: 1972-03 Impact factor: 2.953

10. Suppressive effects of indomethacin on crystal-induced inflammation in canine joints and on neutrophilic motility in vitro.

Authors: P Phelps; D J McCarty
Journal: J Pharmacol Exp Ther Date: 1967-12 Impact factor: 4.030

13 in total

1. Inhibition of cytokine production and adhesion molecule expression by ibuprofen is without effect on transendothelial migration of monocytes.

Authors: E J Menzel; H Burtscher; G Kolarz
Journal: Inflammation Date: 1999-06 Impact factor: 4.092

2. Vascular permeability responses and the role of prostaglandin E2 in an experimental allergic inflammation of air pouch type in rats.

Authors: N Hirasawa; K Ohuchi; K Sugio; S Tsurufuji; M Watanabe; S Yoshino
Journal: Br J Pharmacol Date: 1986-04 Impact factor: 8.739

Action of nonsteroidal, anti-inflammatory drugs on human and rat peripheral leucocyte migration in vitro.

1. In vitro cell migration as a model for delayed hypersensitivity.

2. The effect of aspirin on serum indomethacin.

3. Effect of some drugs on the chemotaxis of rabbit neutrophils in vitro.

4. Prostaglandins, leucocytes and non-steroidal anti-inflammatory drugs.

5. Studies on anti-inflammatory agents. XXV. Effects of anti-inflammatory agents on leucocyte emigration in carrageenin-peritonitis of rats.

6. Competition between salicylate and other drugs in binding to human serum protein in vitro.

7. Standardization of the leucocyte migration test.

8. Hydrocortisone and the migration of human leucocytes: an indirect effect mediated by mononuclear cells.

9. Indomethacin: plasma concentrations and protein binding in man.

10. Suppressive effects of indomethacin on crystal-induced inflammation in canine joints and on neutrophilic motility in vitro.

1. Inhibition of cytokine production and adhesion molecule expression by ibuprofen is without effect on transendothelial migration of monocytes.

2. Vascular permeability responses and the role of prostaglandin E2 in an experimental allergic inflammation of air pouch type in rats.

3. In vitro effects of non-steroidal anti-inflammatory drugs on human polymorphonuclear cells and lymphocyte migration.

4. Polymorphonuclear cell motility, ankylosing spondylitis, and HLA B27.

Review 5. Use of modulators of airways inflammation in patients with CF.

6. Paracetamol versus placebo: effects on post-operative course.

7. Ibuprofen in canine endotoxin shock.

8. Chemotactic competence of neutrophils from neonatal calves. Functional comparison with neutrophils from adult cattle.

9. The effects of some antirheumatic drugs on an in vitro model of human polymorphonuclear leucocyte chemokinesis.

10. In vivo modulation of leukotaxis by non-steroidal anti-inflammatory drugs.