Literature DB >> 567532

Monoclonal antibodies as probes for differentiation and tumor-associated antigens: a Forssman specificity on teratocarcinoma stem cells.

P L Stern, K R Willison, E Lennox, G Galfrè, C Milstein, D Secher, A Ziegler.   

Abstract

A set of monoclonal antibodies derived by fusing P3-NS1/1-Ag4-1 myeloma cells with spleen cells from a rat immunized with mouse spleen were screened for activity against a tumor cell panel. One of these antibodies was found to react only with mouse embryonal carcinoma cells and no other tumor cell type tested, including differentiated derivatives of teratocarcinomas. In the adult mouse, this antigen is expressed by subpopulations of cells in the spleen, bone marrow, lymph node, brain, kidney and testes, although not in liver and thymus. This antigen has a species and tissue distribution consistent with that of Forssman antigen. The molecules which carry this specificity on the embryonal carcinoma cells appear to be glycolipids.

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Year:  1978        PMID： 567532     DOI： 10.1016/0092-8674(78)90333-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  23 in total

Review 1.  Discovering pluripotency: 30 years of mouse embryonic stem cells.

Authors:  Martin Evans
Journal:  Nat Rev Mol Cell Biol       Date:  2011-09-23       Impact factor: 94.444

2.  Immunochemical characterization of surface antigens of TerC, a teratocarcinoma-derived cell line.

Authors:  V Larraga; M Edidin
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

3.  Saccharide orientation at the cell surface affects glycolipid receptor function.

Authors:  N Strömberg; P G Nyholm; I Pascher; S Normark
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

4.  Use of a monoclonal antibody specifically non-reactive with T cells to delineate lymphocyte subpopulations.

Authors:  F Takei; D S Secher; C Milstein; T Springer
Journal:  Immunology       Date:  1981-03       Impact factor: 7.397

Review 5.  Some properties and applications of monoclonal antibodies.

Authors:  P A Edwards
Journal:  Biochem J       Date:  1981-10-15       Impact factor: 3.857

6.  Monoclonal antibodies reacting with murine teratocarcinoma cells.

Authors:  P N Goodfellow; J R Levinson; V E Williams; H O McDevitt
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

7.  Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).

Authors:  D Solter; B B Knowles
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

8.  Isolation and quantitation of the platelet membrane glycoprotein deficient in thrombasthenia using a monoclonal hybridoma antibody.

Authors:  R P McEver; N L Baenziger; P W Majerus
Journal:  J Clin Invest       Date:  1980-12       Impact factor: 14.808

9.  Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin.

Authors:  R J Youle; D M Neville
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205

10.  Monoclonal antibody to a plasma membrane antigen of neurons.

Authors:  G S Eisenbarth; F S Walsh; M Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205
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