| Literature DB >> 567439 |
E Thiermann, W Apt, A Atias, M Lorca, J Olguín.
Abstract
The effectiveness of five treatment regimens was compared to mice during acute and late infection with Toxoplasma gondii. Parasitic cure rates, as judged by failure of brain tissue from surviving mice to produce infection when inoculated into clean mice, were as follows: pyrimethamine + sulfamethoxypyridazine, 92%; clindamycin + sulfamethoxypyridazine, 75%; spiramycin + sulfamethoxypyridazine, 16.7%; trimethoprim + sulfamethoxypryridazine alone, 0%. Pyrimethamine + sulfamethoxypyridazine was the most effective combination against acute toxoplasmosis in mice.Entities:
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Year: 1978 PMID： 567439 DOI： 10.4269/ajtmh.1978.27.747
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345