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Literature DB >> 2069389

Effect of clindamycin on pneumonia from reactivation of Toxoplasma gondii infection in mice.

Abstract

Clindamycin was used to treat the reactivation of a chronic Toxoplasma gondii infection in mice. Clindamycin reduced mortality by 44% when used prophylactically (P less than 0.001) but appeared to be less effective when used to treat clinically apparent reactivation. Further studies should be conducted to establish the efficacy of clindamycin for the treatment of toxoplasmosis in humans.

Entities: Chemical Disease Species

Mesh：

Substances：
Clindamycin

Year: 1991 PMID： 2069389 PMCID： PMC245100 DOI： 10.1128/AAC.35.4.780

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

19 in total

1. In vivo activity of piritrexim [corrected] against Toxoplasma gondii.

Authors: F G Araujo; D R Guptill; J S Remington
Journal: J Infect Dis Date: 1987-11 Impact factor: 5.226

2. Potent in vivo activity of arprinocid, a purine analogue, against murine toxoplasmosis.

Authors: B J Luft
Journal: J Infect Dis Date: 1986-10 Impact factor: 5.226

3. The effect of two chlorinated lincomycin analogues against acute toxoplasmosis in mice.

Authors: P R McMaster; K G Powers; J F Finerty; M N Lunde
Journal: Am J Trop Med Hyg Date: 1973-01 Impact factor: 2.345

4. Pulmonary toxoplasmosis.

Authors: J R Catterall; J M Hofflin; J S Remington
Journal: Am Rev Respir Dis Date: 1986-04

5. Effect of clindamycin on acute and chronic toxoplasmosis in mice.

Authors: F G Araujo; J S Remington
Journal: Antimicrob Agents Chemother Date: 1974-06 Impact factor: 5.191

6. In vivo synergism of roxithromycin (RU 965) and interferon against Toxoplasma gondii.

Authors: J M Hofflin; J S Remington
Journal: Antimicrob Agents Chemother Date: 1987-02 Impact factor: 5.191

7. New micromethod to study the effect of antimicrobial agents on Toxoplasma gondii: comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin, metronidazole, and cyclosporin A.

Authors: D G Mack; R McLeod
Journal: Antimicrob Agents Chemother Date: 1984-07 Impact factor: 5.191

Effect of clindamycin on pneumonia from reactivation of Toxoplasma gondii infection in mice.

1. In vivo activity of piritrexim [corrected] against Toxoplasma gondii.

2. Potent in vivo activity of arprinocid, a purine analogue, against murine toxoplasmosis.

3. The effect of two chlorinated lincomycin analogues against acute toxoplasmosis in mice.

4. Pulmonary toxoplasmosis.

5. Effect of clindamycin on acute and chronic toxoplasmosis in mice.

6. In vivo synergism of roxithromycin (RU 965) and interferon against Toxoplasma gondii.

7. New micromethod to study the effect of antimicrobial agents on Toxoplasma gondii: comparison of sulfadoxine and sulfadiazine individually and in combination with pyrimethamine and study of clindamycin, metronidazole, and cyclosporin A.

8. Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys.

9. Toxoplasmic encephalitis in patients with acquired immune deficiency syndrome.

10. Clindamycin in a murine model of toxoplasmic encephalitis.

1. Effect of clindamycin on intracellular replication, protein synthesis, and infectivity of Toxoplasma gondii.

2. Paradoxical effect of clindamycin in experimental, acute toxoplasmosis in cats.

3. Assessment of spiramycin-loaded chitosan nanoparticles treatment on acute and chronic toxoplasmosis in mice.

4. Synergistic effect of clindamycin and atovaquone in acute murine toxoplasmosis.