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Literature DB >> 5653212

Study of purine metabolism in a xanthinuric female.

M J Bradford, I H Krakoff, R Leeper, M E Balis.

Abstract

A case of xanthinuria is briefly described, and the results of in vivo studies with (14)C-labeled oxypurines are discussed. The data demonstrate that the rate of the turnover of uric acid is normal, despite an extremely small uric acid pool. Xanthine and hypoxanthine pools were measured and their metabolism evaluated. The bulk of the daily pool of 276 mg of xanthine, but only 6% of the 960 mg of hypoxanthine, is excreted. Thus, xanthine appears to be a metabolic end product, whereas hypoxanthine is an active intermediate. Biochemical implications of this finding are discussed.

Entities: Chemical Disease

Mesh：

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Year: 1968 PMID： 5653212 PMCID： PMC297288 DOI： 10.1172/JCI105824

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

19 in total

1. XANTHINURIA AND HEMOCHROMATOSIS.

Authors: J H AYVAZIAN
Journal: N Engl J Med Date: 1964-01-02 Impact factor: 91.245

2. Augmentation of the incorporation of hypoxanthine into nucleic acids by the administration of an inhibitor of xanthine oxidase.

Authors: R POMALES; S BIEBER; R FRIEDMAN; G H HITCHINGS
Journal: Biochim Biophys Acta Date: 1963-05-28

Study of purine metabolism in a xanthinuric female.

1. XANTHINURIA AND HEMOCHROMATOSIS.

2. Augmentation of the incorporation of hypoxanthine into nucleic acids by the administration of an inhibitor of xanthine oxidase.

3. Uric acid production in gout.

4. The preparation and characterization of ribonucleic acids from yeast.

5. Xanthinuria, an inborn error (or deviation) of metabolism.

6. Incorporation of glycine nitrogen into uric acid in normal and gouty man.

7. Allopurinol in the treatment of gout.

8. Urinary metabolites in congenital hyperuricosuria.

9. Study of the utilization and excretion of dietary purines in a xanthinuric man.

10. Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis.

1. Developmental changes in purine phosphoribosyltransferases in human and rat tissues.

2. Validation and steady-state analysis of a power-law model of purine metabolism in man.

3. Xanthine oxidase deficiency and 'Dalmatian' hypouricaemia: incidence and effect of exercise.

4. Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency.

5. Hereditary xanthinuria. Evidence for enhanced hypoxanthine salvage.

6. Lesch-Nyhan syndrome and its pathogenesis: purine concentrations in plasma and urine with metabolite profiles in CSF.