Literature DB >> 565299

Mammalian spot test with moxnidazole, a 5-nitroimidazole.

R Lang.   

Abstract

Moxnidazole [3-(5-nitrol-1-methyl-2-imidazolyl)-methyleneamino-5-morpholinomethyl-2-oxazolidinone, HCl], known to be mutagenic in microbial tests and Drosophila, induced genetic alterations in somatic cells of mice. Ethyl methanesulfonate (EMS) served as positive control.

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Year:  1978        PMID： 565299     DOI： 10.1007/bf01935953

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  11 in total

1.  Radiation-Induced Presumed Somatic Mutations in the House Mouse.

Authors:  L B Russell; M H Major
Journal:  Genetics       Date:  1957-03       Impact factor: 4.562

2.  A mammalian spot test: induction of genetic alterations in pigment cells of mouse embryos with x-rays and chemical mutagens.

Authors:  R Fahrig
Journal:  Mol Gen Genet       Date:  1975-07-10

3.  The mammalian spot test (Fellfleckentest) with mice.

Authors:  R Fahrig
Journal:  Arch Toxicol       Date:  1977-09-21       Impact factor: 5.153

4.  Chemically induced presumed somatic mutations in the mouse.

Authors:  G E Davidson; G W Dawson
Journal:  Mutat Res       Date:  1976-04       Impact factor: 2.433

5.  Mutagenicity of metronidazole: structure-activity relationships.

Authors:  H S Rosenkranz; W T Speck; J E Stambaugh
Journal:  Mutat Res       Date:  1976-06       Impact factor: 2.433

6.  The mutagenic action of nitroimidazoles. I. Metronidazole, nimorazole, dimetridazole and ronidazole.

Authors:  C E Voogd; J J Van der Stel; J J Jacobs
Journal:  Mutat Res       Date:  1974-12       Impact factor: 2.433

7.  Induction of lung tumors and malignant lymphomas in mice by metronidazole.

Authors:  M Rustia; P Shubik
Journal:  J Natl Cancer Inst       Date:  1972-03       Impact factor: 13.506

8.  The contribution of metronidazole and two metabolites to the mutagenic activity detected in urine of treated humans and mice.

Authors:  T H Connor; M Stoeckel; J Evrard; M S Legator
Journal:  Cancer Res       Date:  1977-02       Impact factor: 12.701

9.  The mutagenic action of nitroimidazoles. II. Tinidazole, ipronidazole, panidazole and ornidazole.

Authors:  C E Voogd; J J Van der Stel; J J Jacobs
Journal:  Mutat Res       Date:  1977-04       Impact factor: 2.433

10.  Detection of mutagenic activity of metronidazole and niridazole in body fluids of humans and mice.

Authors:  M S Legator; T H Connor; M Stoeckel
Journal:  Science       Date:  1975-06-13       Impact factor: 47.728
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