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Literature DB >> 56459

Purification and serological characterization of the major envelope glycoprotein from AKR murine leukemia virus and its reactivity with autogenous immune sera from mice.

Abstract

The major envelope glycoprotein (gp71) from AKR murine leukemia virus (MuLV) was purified and its serological reactivity with heterologous and autogenous immune mouse sera was examined. Homologous and interspecies competition radioimmunoassays using antisera to Rauscher-MulV gp69/71 or Friend-MuLV gp71 or antisera to feline leukemia virus to precipitate 125I-labeled gp71 from various MuLV showed that distinct differences exist between Rauscher- or Friend-MuLV and AKR-MuLV glycoproteins. Characteristically the AKR-MuLV gp71, in contrast to FLV or RLV gp71, does not compete fully in homologous or interspecies radioimmunoassays with iodinated Friend of Rauscher glycoproteins. Purified 125I-labeled AKR-MuLV gp71, in contrast to the Rauscher- or Friend-MuLV glycoproteins, reacts with normal (autogenous immune) mouse sera in direct radioimmune precipitation assays. Competition experiments further demonstrate that this is a predominant immunological reactivity of normal mouse sera which had previously been detected by radioimmune precipitation assay against intact virions.

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Year: 1976 PMID： 56459 PMCID： PMC515471

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

24 in total

1. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.

Authors: F C GREENWOOD; W M HUNTER; J S GLOVER
Journal: Biochem J Date: 1963-10 Impact factor: 3.857

2. [Production of substantial amounts of Friend leukemia virus by a suspension tissue culture line (Eveline suspension cells) (author's transl)].

Authors: E Seifert; M Claviez; H Frank; G Hunsmann; H Schwarz; W Schäfer
Journal: Z Naturforsch C Biosci Date: 1975 Sep-Oct

3. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

4. Pathogenic properties, and "vertical" transmission of the mouse leukemia agent.

Authors: L GROSS
Journal: Proc Soc Exp Biol Med Date: 1951-10

5. Structural proteins of oncogenic ribonucleic acid viruses. Interspec II, a new interspecies antigen.

Authors: M Strand; J T August
Journal: J Biol Chem Date: 1973-08-25 Impact factor: 5.157

6. Polypeptides of mammalian oncornaviruses. I. Isolation and serological analysis polypeptides from murine and feline C-type viruses.

Authors: R W Green; D P Bolognesi; W Schäfer; L Pister; G Hunsmann; F De Noronha
Journal: Virology Date: 1973-12 Impact factor: 3.616

7. Cell-surface antigens induced by avian RNA tumor viruses: detection by immunoferritin technique.

Authors: H Gelderblom; H Bauer; T Graf
Journal: Virology Date: 1972-02 Impact factor: 3.616

8. Polypeptides of avian RNA tumor viruses. IV. Components of the viral envelope.

Authors: D P Bolognesi; H Bauer; H Gelderblom; G Hüper
Journal: Virology Date: 1972-03 Impact factor: 3.616

9. Coexistence of intraspecies and interspecies specific antigenic determinants on the major structural polypeptide of mammalian C-type viruses.

Authors: R V Gilden; S Oroszlan; R J Huebner
Journal: Nat New Biol Date: 1971-05-26

10. Biochemical evidence linking the GIX thymocyte surface antigen to the gp69/71 envelope glycoprotein of murine leukemia virus.

Authors: J S Tung; E S Vitetta; E Fleissner; E A Boyse
Journal: J Exp Med Date: 1975-01-01 Impact factor: 14.307

25 in total

1. Serological characterization of B-tropic viruses of C57BL mice: possible origin by recombination of endogenous N-tropic and xenotropic viruses.

Authors: L E Benade; J N Ihle; A Declève
Journal: Proc Natl Acad Sci U S A Date: 1978-09 Impact factor: 11.205

2. Amino- and carboxyl-terminal amino acid sequences of proteins coded by gag gene of murine leukemia virus.

Authors: S Oroszlan; L E Henderson; J R Stephenson; T D Copeland; C W Long; J N Ihle; R V Gilden
Journal: Proc Natl Acad Sci U S A Date: 1978-03 Impact factor: 11.205

3. AKR-MuLV-associated cell surface antigens.

Authors: J N Ihle; J D Longstreth; N H Pazmiño; W L McLellan; M G Hanna
Journal: Med Microbiol Immunol Date: 1977 Impact factor: 3.402

4. The immune response of (C57BL/6 X C3H)F1 mice to the endogenous AKR-MuLV.

Authors: J N Ihle; J C Lee
Journal: Med Microbiol Immunol Date: 1977 Impact factor: 3.402

5. Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses.

Authors: Y H Chien; I M Verma; T Y Shih; E M Scolnick; N Davidson
Journal: J Virol Date: 1978-10 Impact factor: 5.103

6. Biochemical and immunological characterization of the major envelope glycoprotein gp69/71 and degradation fragments from Rauscher leukemia virus.

Authors: M J Krantz; M Strand; J T August
Journal: J Virol Date: 1977-06 Impact factor: 5.103

7. Oncogenic and immunogenic potential of cloned HIX virus in mice and cats.

Authors: P J Fischinger; J N Ihle; F de Noronha; D P Bolognesi
Journal: Med Microbiol Immunol Date: 1977 Impact factor: 3.402

8. Envelope polypeptides of Friend leukemia virus: purification and structural analysis.

Authors: J Schneider; H Falk; G Hunsmann
Journal: J Virol Date: 1980-02 Impact factor: 5.103

9. Natural immunity in mice to the envelope glycoprotein of endogenous ecotropic type C viruses: neutralization of virus infectivity.

Authors: J N Ihle; B Lazar
Journal: J Virol Date: 1977-03 Impact factor: 5.103

10. Role of carbohydrate in biological functions of Friend murine leukemia virus gp71.

Authors: W Schäfer; P J Fischinger; J J Collins; D P Bolognesi
Journal: J Virol Date: 1977-01 Impact factor: 5.103