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Literature DB >> 212606

Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses.

Y H Chien, I M Verma, T Y Shih, E M Scolnick, N Davidson.

Abstract

The sequence relationships betwen AKR ecotropic virus and an AKR-derived "mink cell focus-inducing" (MCF) isolate (AKR MCF 247), between Moloney murine leukemia virus (M-MLV) and an M-MLV MCF isolate (M-MLV83), and between AKR and M-MLV were studied by electron microscopic heteroduplex analysis. The MCF-specific sequences were found to map from 1.95 kilobases (kb) to 2.75 kb (+/- 0.15 kb) from the 3' end of the RNAs for both MCF isolates. The major sequence nonhomology regions between AKR and M-MLV lie between 0.9 and 3.5 kb from the 3' end. However, the AKR and M-MLV sequences immediately adjacent to the 1.95- and 2.75-kb junctions with MCF-specific sequences are relatively similar in AKR and M-MLV. Our results suggest that the env gene of MLVs maps from 1 kb to 3 kb from the 3' end of the genomic RNA and that the carboxyl end of the glycoprotein of each MCF strain is similar (or identical) to that of its ecotropic parent.

Entities: Disease Gene Species

Mesh：

Substances：
RNA, Viral

Year: 1978 PMID： 212606 PMCID： PMC354274

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

23 in total

1. Heteroduplex analysis of avian RNA tumor viruses.

Authors: R P Junghans; S Hu; C A Knight; N Davidson
Journal: Proc Natl Acad Sci U S A Date: 1977-02 Impact factor: 11.205

2. Biochemical evidence that MCF murine leukemia viruses are envelope (env) gene recombinants.

Authors: J H Elder; J W Gautsch; F C Jensen; R A Lerner; J W Hartley; W P Rowe
Journal: Proc Natl Acad Sci U S A Date: 1977-10 Impact factor: 11.205

3. Characterization and mapping of RNase T1-resistant oligonucleotides derived from the genomes of Akv and MCF murine leukemia viruses.

Authors: J Rommelaere; D V Faller; N Hopkins
Journal: Proc Natl Acad Sci U S A Date: 1978-01 Impact factor: 11.205

4. Genome organization of RNA tumor viruses. I. In vitro synthesis of full-genome-length single-stranded and double-stranded viral DNA transcripts.

Authors: I M Verma
Journal: J Virol Date: 1978-06 Impact factor: 5.103

5. Friend strain of spleen focus-forming virus is a recombinant between ecotropic murine type C virus and the env gene region of xenotropic type C virus.

Authors: D H Troxler; D Lowy; R Howk; H Young; E M Scolnick
Journal: Proc Natl Acad Sci U S A Date: 1977-10 Impact factor: 11.205

6. Translation of MuLV and MSV RNAs in nuclease-treated reticulocyte extracts: enhancement of the gag-pol polypeptide with yeast suppressor tRNA.

Authors: L Philipson; P Andersson; U Olshevsky; R Weinberg; D Baltimore; R Gesteland
Journal: Cell Date: 1978-01 Impact factor: 41.582

7. Ordered transcription of RNA tumor virus genomes.

Authors: W A Haseltine; D G Kleid; A Panet; E Rothenberg; D Baltimore
Journal: J Mol Biol Date: 1976-09-05 Impact factor: 5.469

8. Polymorphism of the major envelope glycoprotein (gp70) of murine C-type viruses: virion associated and differentiation antigens encoded by a multi-gene family.

Authors: J H Elder; F C Jensen; M L Bryant; R A Lerner
Journal: Nature Date: 1977-05-05 Impact factor: 49.962

9. A new class of murine leukemia virus associated with development of spontaneous lymphomas.

Authors: J W Hartley; N K Wolford; L J Old; W P Rowe
Journal: Proc Natl Acad Sci U S A Date: 1977-02 Impact factor: 11.205

10. Analysis of a 5' leader sequence on murine leukemia virus 21S RNA: heteroduplex mapping with long reverse transcriptase products.

Authors: E Rothenberg; D J Donoghue; D Baltimore
Journal: Cell Date: 1978-03 Impact factor: 41.582

47 in total

1. A small region of the ecotropic murine leukemia virus (MuLV) gag gene profoundly influences the types of polytropic MuLVs generated in mice.

Authors: M Lavignon; J Richardson; L H Evans
Journal: J Virol Date: 1997-11 Impact factor: 5.103

2. Antigenic subclasses of polytropic murine leukemia virus (MLV) isolates reflect three distinct groups of endogenous polytropic MLV-related sequences in NFS/N mice.

Authors: Leonard H Evans; Marc Lavignon; Marc Taylor; A S M Alamgir
Journal: J Virol Date: 2003-10 Impact factor: 5.103

3. Generation of mink cell focus-forming viruses by Friend murine leukemia virus: recombination with specific endogenous proviral sequences.

Authors: L H Evans; M W Cloyd
Journal: J Virol Date: 1984-03 Impact factor: 5.103

4. Leukemogenesis by Gross passage A murine leukemia virus: expression of viruses with recombinant env genes in transformed cells.

Authors: N G Famulari; C F Koehne; P V O'Donnell
Journal: Proc Natl Acad Sci U S A Date: 1982-06 Impact factor: 11.205

5. Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse.

Authors: C Blatt; K Mileham; M Haas; M N Nesbitt; M E Harper; M I Simon
Journal: Proc Natl Acad Sci U S A Date: 1983-10 Impact factor: 11.205

6. Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigens.

Authors: J C Wejman; B A Taylor; N A Jenkins; N G Copeland
Journal: J Virol Date: 1984-04 Impact factor: 5.103

7. Monoclonal AKR/J thymic leukemias contain multiple JH immunoglobulin gene rearrangements.

Authors: W Herr; A P Perlmutter; W Gilbert
Journal: Proc Natl Acad Sci U S A Date: 1983-12 Impact factor: 11.205

8. Free and integrated recombinant murine leukemia virus DNAs appear in preleukemic thymuses of AKR/J mice.

Authors: W Herr; W Gilbert
Journal: J Virol Date: 1984-04 Impact factor: 5.103

9. Nucleotide sequence analysis establishes the role of endogenous murine leukemia virus DNA segments in formation of recombinant mink cell focus-forming murine leukemia viruses.

Authors: A S Khan
Journal: J Virol Date: 1984-06 Impact factor: 5.103

10. Cloning of endogenous murine leukemia virus-related sequences from chromosomal DNA of BALB/c and AKR/J mice: identification of an env progenitor of AKR-247 mink cell focus-forming proviral DNA.

Authors: A S Khan; W P Rowe; M A Martin
Journal: J Virol Date: 1982-11 Impact factor: 5.103