Literature DB >> 56397

Modulation of help and suppression in a hapten-carrier system.

D D Eardley, E E Sercarz.   

Abstract

Provision of beta-galactosidase (GZ) under defined conditions of dose and time can either help or suppress a subsequent response to trinitrophenyl (TNP)-GZ in CBA/J mice. The optimal helper effect occurs when 10(7) spleen cells from mice primed 9 or more days previously with 10 mug GZ are adoptively transferred to irradiated recipients which are than challenged with 10 mug TNP50GZ. Optimum suppression results from the transfer of spleen cells from mice primed 3 days previously with 100 mug GZ and challenge of recipients with TMP150GZ. Both help and suppression are carrier-specific and mediated by T cells. In experiments where helper or suppressor cells were mixed with normal cells, the anti-TNP response was proportional to the number of primed cells transferred. The results point to a wave of suppression as the initial event after immunization, which is succeeded by period in which the helper effect dominates.

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Year:  1976        PMID: 56397

Source DB:  PubMed          Journal:  J Immunol        ISSN: 0022-1767            Impact factor:   5.422


  8 in total

1.  Effect of age and pregnancy on the antibody and cell-mediated immune responses of horses to equine herpesvirus 1.

Authors:  J D Gerber; A E Marron; E P Bass; W H Beckenhauer
Journal:  Can J Comp Med       Date:  1977-10

2.  Separation of helper and suppressor T lymphocytes. II. Ly phenotypes and lack of DNA synthesis requirement for the generation of concanavalin A helper and suppressor cells.

Authors:  H Y Tse; R W Dutton
Journal:  J Exp Med       Date:  1977-09-01       Impact factor: 14.307

3.  B-memory cells can be stimulated by antigen in vitro to become IgG antibody-secreting cells.

Authors:  J R North; R M Maizels
Journal:  Immunology       Date:  1977-05       Impact factor: 7.397

Review 4.  Function of macrophages as antigen presenting cells.

Authors:  J Schroer; A S Rosenthal
Journal:  Springer Semin Immunopathol       Date:  1980-08

5.  Key antigenic determinants in regulation of the immune response.

Authors:  D Turkin; E E Sercarz
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

6.  Effect of colchicine on the antibody response. II. Demonstration of the inactivation of suppressor cell activities by colchicine.

Authors:  P N Shek; C Waltenbaugh; A H Coons
Journal:  J Exp Med       Date:  1978-04-01       Impact factor: 14.307

Review 7.  The Anti-DNA Antibodies: Their Specificities for Unique DNA Structures and Their Unresolved Clinical Impact-A System Criticism and a Hypothesis.

Authors:  Ole Petter Rekvig
Journal:  Front Immunol       Date:  2022-01-11       Impact factor: 7.561

8.  Effect of colchicine on the antibody response. I. Enhancement of antibody formation in mice.

Authors:  P N Shek; A H Coons
Journal:  J Exp Med       Date:  1978-04-01       Impact factor: 14.307

  8 in total

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