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1. Prediction of in vivo tissue distribution from in vitro data. 3. Correlation between in vitro and in vivo tissue distribution of a homologous series of nine 5-n-alkyl-5-ethyl barbituric acids.

Authors: Peter Ballard; David E Leahy; Malcolm Rowland
Journal: Pharm Res Date: 2003-06 Impact factor: 4.200

Review 2. How medicinal chemists learned about log P.

Authors: Yvonne Connolly Martin
Journal: J Comput Aided Mol Des Date: 2018-07-17 Impact factor: 3.686

3. Prediction of hepatic first-pass metabolism and plasma levels following intravenous and oral administration of barbiturates in the rabbit based on quantitative structure-pharmacokinetic relationships.

Authors: N Watari; Y Sugiyama; N Kaneniwa; M Hiura
Journal: J Pharmacokinet Biopharm Date: 1988-06

4. Structure-toxicity relationships for unsaturated alcohols to Tetrahymena pyriformis: C5 and C6 analogs and primary propargylic alcohols.

Authors: T W Schultz; M Tichy
Journal: Bull Environ Contam Toxicol Date: 1993-11 Impact factor: 2.151

5. Investigations on the structure-activity relationships of verapamil.

Authors: R Mannhold; R Steiner; W Haas; R Kaufmann
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1978-04 Impact factor: 3.000

6. Evaluation of mono- and dibenzoyl esters of dopamine as potential pro-drugs for dopamine in the central nervous system.

Authors: S M Tejani-Butt; M Hauptmann; A D'Mello; A Frazer; J M Marcoccia; D J Brunswick
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1988-11 Impact factor: 3.000

The parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics.

1. Prediction of in vivo tissue distribution from in vitro data. 3. Correlation between in vitro and in vivo tissue distribution of a homologous series of nine 5-n-alkyl-5-ethyl barbituric acids.

Review 2. How medicinal chemists learned about log P.

3. Prediction of hepatic first-pass metabolism and plasma levels following intravenous and oral administration of barbiturates in the rabbit based on quantitative structure-pharmacokinetic relationships.

4. Structure-toxicity relationships for unsaturated alcohols to Tetrahymena pyriformis: C5 and C6 analogs and primary propargylic alcohols.

5. Investigations on the structure-activity relationships of verapamil.

6. Evaluation of mono- and dibenzoyl esters of dopamine as potential pro-drugs for dopamine in the central nervous system.

Review 7. Hydrophobicity--shake flasks, protein folding and drug discovery.

Review 8. Medicinal chemical properties of successful central nervous system drugs.

9. Studies on the mechanism of acute toxicity of nitriles in mice.

10. Effect of organic nitrates on myocardial oxygen consumption in vitro.