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Literature DB >> 561952

The structure of the chromatin core particle in solution.

J F Pardon, D L Worcester, J C Wooley, R I Cotter, D M Lilley, R M Richards.

Abstract

The shape and size of the nucleosomal core particle from chromatin has been examined by analysis of neutron and X-ray scattering data from dilute solutions. Calculations of scattering for many different models have been made and only one model was able to account for both the X-ray and neutron profiles. This model is an oblate structure with height about 50A and diameter 110A. The DNA is mainly confined to two annuli located at the top and bottom respectively of the core particle positioned on the outside of a compact protein core which has a height of about 40A and diameter about 73A.

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Year: 1977 PMID： 561952 PMCID： PMC342644 DOI： 10.1093/nar/4.9.3199

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

36 in total

10. Selective deuteration of tryptophan and methionine residues in maltose binding protein: a model system for neutron scattering.

Authors: Valerie Laux; Phil Callow; Dmitri I Svergun; Peter A Timmins; V Trevor Forsyth; Michael Haertlein
Journal: Eur Biophys J Date: 2008-02-15 Impact factor: 1.733

The structure of the chromatin core particle in solution.

1. THE STRUCTURE OF NUCLEOHISTONES AND NUCLEOPROTAMINES.

2. Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei.

3. Low-angle neutron scattering from chromatin subunit particles.

4. Organisation of subunits in chromatin.

5. The molecular weight of nucleosome protein by laser light scattering.

6. Spheroid chromatin units (v bodies).

7. The sub-structure of nucleosomes.

8. Small angle neutron scattering studies of chromatin subunits in solution.

9. Comparative organization of active transcription units in Oncopeltus fasciatus.

10. Structural investigations of chromatin core protein by nuclear magnetic resonance.

Review 1. On the biological role of histone acetylation.

2. Experimental evidence for asymmetrical shielding of nucleosomal DNA by histones.

3. Cross-linking of nucleosomal histones with monofunctional imidoesters.

4. Characterization of the histone core complex.

5. Compact oligomers and nucleosome phasing.

6. Histone packing in the nucleosome core particle of chromatin.

7. DNA wrapping in nucleosomes. The linking number problem re-examined.

8. Nucleosome core histone complex isolated gently and rapidly in 2 M NaCl is octameric.

9. In vitro core particle and nucleosome assembly at physiological ionic strength.

10. Selective deuteration of tryptophan and methionine residues in maltose binding protein: a model system for neutron scattering.