Literature DB >> 561154

Biosynthesis of pro-C3, a precursor of the third component of complement.

V Brade, R E Hall, H R Colten.   

Abstract

A precusor of the third component of complement, pro-C3, was detected in studies of cell-free synthesis and intracellularly in homogenates of liver tissue cultures. The molecular weight of pro-C3 was indistinguishable from that of intact native C3 secreted in vitro by liver or peritoneal macrophages, but its structure was different. Pro-C3 is a single polypeptide chain, whereas C3 secreted by cells in culture consists of two polypeptide chains (mol wt 120,000 and 76,000) linked by disulfide bonds.

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Year:  1977        PMID： 561154      PMCID： PMC2180790          DOI： 10.1084/jem.146.3.759

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  17 in total

Review 1.  Complement.

Authors:  H J Müller-Eberhard
Journal:  Annu Rev Biochem       Date:  1975       Impact factor: 23.643

2.  Interaction of C3b, B, and D in the alternative pathway of complement activation.

Authors:  A Nicholson; V Brade; H U Schorlemmer; R Burger; D Bitter-Suermann; U Hadding
Journal:  J Immunol       Date:  1975-10       Impact factor: 5.422

3.  Molecular size and subunit structure of the fourth component of guinea pig complement.

Authors:  R E Hall; H R Colten
Journal:  J Immunol       Date:  1977-05       Impact factor: 5.422

Review 4.  Proteolytic processing in the biosynthesis of insulin and other proteins.

Authors:  D F Steiner; W Kemmler; H S Tager; J D Peterson
Journal:  Fed Proc       Date:  1974-10

5.  Polyribosomal synthesis and assembly of the H and L chains of gamma globulin.

Authors:  A L Shapiro; M D Scharff; J V Maizel; J W Uhr
Journal:  Proc Natl Acad Sci U S A       Date:  1966-07       Impact factor: 11.205

6.  Ontogeny of the human complement system: in vitro biosynthesis of individual complement components by fetal tissues.

Authors:  H R Colten
Journal:  J Clin Invest       Date:  1972-04       Impact factor: 14.808

7.  In vitro synthesis of factor B of the alternative pathway of complement activation by mouse peritoneal macrophages.

Authors:  C Bentley; D Bitter-Suermann; U Hadding; V Brade
Journal:  Eur J Immunol       Date:  1976-06       Impact factor: 5.532

8.  Human C3 and C5: subunit structure and modifications by trypsin and C42-C423.

Authors:  U R Nilsson; R J Mandle; J A McConnell-Mapes
Journal:  J Immunol       Date:  1975-02       Impact factor: 5.422

9.  mRNA-dependent synthesis of authentic precursor to human placental lactogen: conversion to its mature hormone form in ascites cell-free extracts.

Authors:  E Szczesna; I Boime
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

10.  Fourth component of human complement: description of a three polypeptide chain structure.

Authors:  R D Schreiber; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1974-11-01       Impact factor: 14.307
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  20 in total

1.  Synthesis of factors D, B and P of the alternative pathway of complement activation, as well as of C3, by guinea-pig peritoneal macrophages in vitro.

Authors:  C Bentley; W Fries; V Brade
Journal:  Immunology       Date:  1978-12       Impact factor: 7.397

2.  A C3(H20) recycling pathway is a component of the intracellular complement system.

Authors:  Michelle Elvington; M Kathryn Liszewski; Paula Bertram; Hrishikesh S Kulkarni; John P Atkinson
Journal:  J Clin Invest       Date:  2017-02-13       Impact factor: 14.808

3.  Cis- and trans-acting elements required for constitutive and cytokine-regulated expression of the mouse complement C3 gene.

Authors:  N Kawamura; L Singer; R A Wetsel; H R Colten
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

4.  Biosynthesis and secretion of the third component of complement by human endothelial cells in vitro.

Authors:  A Ueki; T Sai; H Oka; M Tabata; K Hosokawa; Y Mochizuki
Journal:  Immunology       Date:  1987-05       Impact factor: 7.397

5.  Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4.

Authors:  L Sottrup-Jensen; T M Stepanik; T Kristensen; P B Lønblad; C M Jones; D M Wierzbicki; S Magnusson; H Domdey; R A Wetsel; A Lundwall
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

Review 6.  Synthesis of complement by macrophages and modulation of their functions through complement activation.

Authors:  H P Hartung; U Hadding
Journal:  Springer Semin Immunopathol       Date:  1983

Review 7.  Complement components in relation to macrophage function.

Authors:  H P Hartung; U Hadding
Journal:  Agents Actions       Date:  1983-08

8.  A general method for affinity purification of complement component C3b using factor H-sepharose.

Authors:  J D Scott; J E Fothergill
Journal:  Biochem J       Date:  1982-09-01       Impact factor: 3.857

9.  Pretranslational regulation of the synthesis of the third component of complement in human mononuclear phagocytes by the lipid A portion of lipopolysaccharide.

Authors:  R C Strunk; A S Whitehead; F S Cole
Journal:  J Clin Invest       Date:  1985-09       Impact factor: 14.808

10.  Complement biosynthesis by the human hepatoma-derived cell line HepG2.

Authors:  K M Morris; D P Aden; B B Knowles; H R Colten
Journal:  J Clin Invest       Date:  1982-10       Impact factor: 14.808
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