Literature DB >> 5581909

Brain serotonin content: physiological dependence on plasma tryptophan levels.

J D Fernstrom, R J Wurtman.   

Abstract

Brain serotonin cocentrations at 1 p.m. were significantly elevated 1 hour after rats received a dose of L-tryptophan (12.5 milligrams per kilogram. intraperitoneally) smaller than one-twentieth of the normal daily dietary intake. Plasma and brain tryptophan levels were elevated 10 to 60 minutes after the injection, but they never exceeded the concentrationis that occur nocturnally in untreated aninmals as result of their normal 24-hour rhythms. These data suggest that physiological changes in plasma tryptophan concentration influenice brain serotonin levels.

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Year:  1971        PMID： 5581909     DOI： 10.1126/science.173.3992.149

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  144 in total

1.  Failure of decreased serotonin uptake or monoamine oxidase inhibition to block the acceleration in brain 5-hydroxyindole synthesis that follows food consumption.

Authors:  J H Jacoby; J L Colmenares; R J Wurtman
Journal:  J Neural Transm       Date:  1975       Impact factor: 3.575

2.  Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating.

Authors:  Kimberly A Brownley; Charlotte A Boettiger; Laura Young; William T Cefalu
Journal:  Med Hypotheses       Date:  2015-03-27       Impact factor: 1.538

Review 3.  α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions.

Authors:  Diane C Chugani
Journal:  Biomark Med       Date:  2011-10       Impact factor: 2.851

4.  5-Hydroxytryptamine (5-HT) in the whole-blood of patients with depressive illness.

Authors:  A Coppen; P Turner; A R Rowsell; C Padgham
Journal:  Postgrad Med J       Date:  1976-03       Impact factor: 2.401

5.  Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: effect of cirrhosis of liver and probenecid administration.

Authors:  S N Young; S Lal; T L Sourkes; F Feldmuller; A Aronoff; J B Martin
Journal:  J Neurol Neurosurg Psychiatry       Date:  1975-04       Impact factor: 10.154

Review 6.  Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses.

Authors:  Richard J Wurtman; Mehmet Cansev; Toshimasa Sakamoto; Ismael Ulus
Journal:  Nutr Rev       Date:  2010-12       Impact factor: 7.110

7.  The dynamic serotonin system of the maternal brain.

Authors:  Joseph S Lonstein
Journal:  Arch Womens Ment Health       Date:  2018-07-21       Impact factor: 3.633

8.  Influence of tryptophan supplementation of soy-based infant formulas on protein quality and on blood and brain tryptophan and brain serotonin in the rat model.

Authors:  G Sarwar
Journal:  Plant Foods Hum Nutr       Date:  2001       Impact factor: 3.921

9.  Transport of nutrients and hormones through the blood-brain barrier.

Authors:  W M Pardridge
Journal:  Diabetologia       Date:  1981-03       Impact factor: 10.122

10.  The anorectic effect of increasing doses of L-tryptophan in obese patients.

Authors:  H Cavaliere; G Medeiros-Neto
Journal:  Eat Weight Disord       Date:  1997-12       Impact factor: 4.652
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