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Literature DB >> 21091953

Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses.

Richard J Wurtman¹, Mehmet Cansev, Toshimasa Sakamoto, Ismael Ulus.

Abstract

Brain phosphatide synthesis requires three circulating compounds: docosahexaenoic acid (DHA), uridine, and choline. Oral administration of these phosphatide precursors to experimental animals increases the levels of phosphatides and synaptic proteins in the brain and per brain cell as well as the numbers of dendritic spines on hippocampal neurons. Arachidonic acid fails to reproduce these effects of DHA. If similar increases occur in human brain, administration of these compounds to patients with diseases that cause loss of brain synapses, such as Alzheimer's disease, could be beneficial.

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Year: 2010 PMID： 21091953 PMCID： PMC3062998 DOI： 10.1111/j.1753-4887.2010.00344.x

Source DB: PubMed Journal: Nutr Rev ISSN： 0029-6643 Impact factor: 7.110

113 in total

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16 in total

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7. A specific dietary intervention to restore brain structure and function after ischemic stroke.

Authors: Maximilian Wiesmann; Bastian Zinnhardt; Dirk Reinhardt; Sarah Eligehausen; Lydia Wachsmuth; Sven Hermann; Pieter J Dederen; Marloes Hellwich; Michael T Kuhlmann; Laus M Broersen; Arend Heerschap; Andreas H Jacobs; Amanda J Kiliaan
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