Literature DB >> 558109

[2-o-Iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin: basic pharmacology and comments on their potential use in binding studies.

V Pliska, P Marbach, J Vasák, J Rudinger.   

Abstract

Both [2-o-iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin display only weak vasopressor and antidiuretic effects on rats. They inhibit the in vitro uterotonic action of oxytocin; this inhibition is not fully competitive. It is concluded that they are not suitable as markers for studies of uterine receptor for oxytocin.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 558109     DOI： 10.1007/bf02002831

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.

Authors:  J M VAN ROSSUM
Journal:  Arch Int Pharmacodyn Ther       Date:  1963

2.  Effect of magnesium ion on the response of the rat uterus to neurohypophysial hormones and analogues.

Authors:  R A MUNSICK
Journal:  Endocrinology       Date:  1960-03       Impact factor: 4.736

3.  The quantitative assay of vasopressin.

Authors:  J DEKANSKI
Journal:  Br J Pharmacol Chemother       Date:  1952-12

4.  Time-response patterns of isolated rat uterus to neurohypophyseal peptides.

Authors:  M Wahrenburg; M Koida; R Walter; V Pliska
Journal:  Experientia       Date:  1975-09-15

5.  The interaction of lysine vasopressin with free and agarose-bound bovine neurophysin II. Two classes of binding sites.

Authors:  V Pliska; H Sachs
Journal:  Eur J Biochem       Date:  1974-01-16

6.  Monoido-oxytocin: demonstration of its biological activity and specific binding to isolated fat cells.

Authors:  E E Thompson; P Freychet; J Roth
Journal:  Endocrinology       Date:  1972-11       Impact factor: 4.736

7.  Purification and stability of specifically tritium labelled lysine vasopressin (tyrosine2-3-T-lysine8-sopressin).

Authors:  L Carlsson; V Pliska; N A Thorn
Journal:  Experientia       Date:  1969

8.  Pharmacological estimation of drug-receptor dissociation constants. Statistical evaluation. I. Agonists.

Authors:  R B Parker; D R Waud
Journal:  J Pharmacol Exp Ther       Date:  1971-04       Impact factor: 4.030

9.  Determination of antidiuretic activity in the rat for structural analogues of the neurohypophysial hormones.

Authors:  V Pliska; I Rychlík
Journal:  Acta Endocrinol (Copenh)       Date:  1967-01

10.  Threshold and receptor reserve in the action of neurohypophyseal peptides. A study of synergists and antagonists of the hydroosmotic response of the toad urinary bladder.

Authors:  P Eggena; I L Schwartz; R Walter
Journal:  J Gen Physiol       Date:  1970-08       Impact factor: 4.086
  10 in total
  2 in total

1.  Affinity of 1,2-substituted oxytocin analogues to the uterus receptor: Free-Wilson and Hansch analysis.

Authors:  V Pliska
Journal:  Experientia       Date:  1978-09-15

Review 2.  Pharmacological versus binding analysis of receptor systems: how do they interplay? Myometrial cell receptors for oxytocin as a paradigm.

Authors:  V Pliska
Journal:  Experientia       Date:  1991-03-15
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.