Literature DB >> 214332

Affinity of 1,2-substituted oxytocin analogues to the uterus receptor: Free-Wilson and Hansch analysis.

V Pliska.   

Abstract

The analysis of pA2 values for 1,2-substituted oxytocin analogues suggests a significant resonance effect of p-substituted groups in 2-tyrosine when the hormone binds to its uterus receptor, whereas the N-terminal amino group exerts less clearly characterized effects (participation of its lipophilicity and molecular volume can be assumed.

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Year:  1978        PMID： 214332     DOI： 10.1007/bf01922951

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  A MATHEMATICAL CONTRIBUTION TO STRUCTURE-ACTIVITY STUDIES.

Authors:  S M FREE; J W WILSON
Journal:  J Med Chem       Date:  1964-07       Impact factor: 7.446

2.  pAx and competitive drug antagonism.

Authors:  H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1949-09

3.  N-acetyl-2-O-methyl-tyrosine-oxytocin: a specific antagonist of oxytocin.

Authors:  I Krejcí; B Kupková; T Barth; K Jost
Journal:  Physiol Bohemoslov       Date:  1973

Review 4.  Oxytocin analogs in the analysis of some phases of hormone action.

Authors:  J Rudinger; V Pliska; I Krejcí
Journal:  Recent Prog Horm Res       Date:  1972

5.  "Aromatic" substituent constants for structure-activity correlations.

Authors:  C Hansch; A Leo; S H Unger; K H Kim; D Nikaitani; E J Lien
Journal:  J Med Chem       Date:  1973-11       Impact factor: 7.446

6.  [2-o-Iodotyrosine]-oxytocin and [2-o-methyltyrosine]-oxytocin: basic pharmacology and comments on their potential use in binding studies.

Authors:  V Pliska; P Marbach; J Vasák; J Rudinger
Journal:  Experientia       Date:  1977-03-15

7.  Effect of lipophilic character on the biological activity of synthetic angiotensin peptides.

Authors:  V L Nouailhetas; C R Nakaie; L Juliano; A C Paiva
Journal:  Biochem J       Date:  1977-09-01       Impact factor: 3.857

8.  Some biological properties of an "irreversible" antagonist of neurohypophyseal hormones, deamino-[Phe(4-BrCH2CONH)2]-oxytocin, and its isosteric analogue, deamino-[Phe(4-CH3CH2CONH)2]-oxytocin.

Authors:  V Pliska; P Marbach
Journal:  Eur J Pharmacol       Date:  1978-06-01       Impact factor: 4.432

9.  Some pharmacological properties of a synthetic oxytocin analogue [1-N-carbamoyl-hemicystine-2-O-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), an antagonist to the neurohypophysial hormones.

Authors:  G W Bisset; B J Clark; I Krejcí; I Polácek; J Rudinger
Journal:  Br J Pharmacol       Date:  1970-10       Impact factor: 8.739
  9 in total

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