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Literature DB >> 5547996

Mechanism of conversion of the salmonella O antigen by bacteriophageepsilon 34.

Abstract

The structural determinants for antigen 34 in the E group salmonella are glucosyl substituents on the galactosyl units of the O antigen which has a mannosylrhamnosylgalactose repeating sequence. The temperate bacteriophage epsilon(34) brings about the production of antigen 34. It has been shown here that glucose is transferred from uridine diphosphate glucose to the O antigen via a glucosyl-lipid intermediate in a two-step reaction. Glucose is linked through carbon 1 to the lipid by a phosphodiester bridge, the glucosyl bond having the beta-anomeric configuration. The lipid is a C(55)-polyisoprenoid alcohol, each isoprene unit having one double bond. It is the same lipid which is involved in the synthesis of the O antigen repeating sequence.

Entities: Chemical Species

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Year: 1971 PMID： 5547996 PMCID： PMC248520 DOI： 10.1128/jb.105.3.927-936.1971

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

21 in total

1. Characterization of a polyisoprenoid compound functional in O-antigen biosynthesis.

Authors: A Wright; M Dankert; P Fennessey; P W Robbins
Journal: Proc Natl Acad Sci U S A Date: 1967-06 Impact factor: 11.205

2. Properties of the O-specific hapten formed in vivo by mutant strains of Salmonella typhimurium.

Authors: J L Kent; M J Osborn
Journal: Biochemistry Date: 1968-12 Impact factor: 3.162

3. Isolation, purification, and properties of the lipid-linked intermediates of O-antigen biosynthesis.

Authors: M Dankert; A Wright; W S Kelley; P W Robbins
Journal: Arch Biochem Biophys Date: 1966-09-26 Impact factor: 4.013

4. Mechanism of epsilon-15 conversion studies with bacteriphage mutants.

Authors: D Bray; P W Robbins
Journal: J Mol Biol Date: 1967-12-28 Impact factor: 5.469

5. Biosynthesis of bacterial lipopolysaccharide. V. Lipid-linked intermediates in the biosynthesis of the O-antigen groups of Salmonella typhimurium.

Authors: I M Weiner; T Higuchi; L Rothfield; M Saltmarsh-Andrew; M J Osborn; B L Horecker
Journal: Proc Natl Acad Sci U S A Date: 1965-07 Impact factor: 11.205

6. A lipid intermediate in mannan biosynthesis in yeast.

Authors: W Tanner
Journal: Biochem Biophys Res Commun Date: 1969-04-10 Impact factor: 3.575

7. Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C55 isoprenoid alcohol.

Authors: Y Higashi; J L Strominger; C C Sweeley
Journal: Proc Natl Acad Sci U S A Date: 1967-06 Impact factor: 11.205

8. The biosynthesis of mannosyl-1-phosphoryl-polyisoprenol in Micrococcus lysodeikticus and its role in mannan synthesis.

Authors: M Scher; W J Lennarz; C C Sweeley
Journal: Proc Natl Acad Sci U S A Date: 1968-04 Impact factor: 11.205

9. Evidence for an intermediate stage in the biosynthesis of the Salmonella O-antigen.

Authors: A Wright; M Dankert; P W Robbins
Journal: Proc Natl Acad Sci U S A Date: 1965-07 Impact factor: 11.205

10. Biosynthesis of the determinant 34 of the Salmonella O-antigen.

Authors: T Uchida; T Makino; K Kurahashi; H Uetake
Journal: Biochem Biophys Res Commun Date: 1965-11-22 Impact factor: 3.575

32 in total

Review 1. Lipopolysaccharide endotoxins.

Authors: Christian R H Raetz; Chris Whitfield
Journal: Annu Rev Biochem Date: 2001-11-09 Impact factor: 23.643

9. Identification of four genes involved in the lysogenic pathway of the Salmonella newington bacterial virus epsilon 34.

Authors: R Villafane; J Black
Journal: Arch Virol Date: 1994 Impact factor: 2.574

10. Genomic analysis of bacteriophage epsilon 34 of Salmonella enterica serovar Anatum (15+).

Authors: Robert Villafane; Milka Zayas; Eddie B Gilcrease; Andrew M Kropinski; Sherwood R Casjens
Journal: BMC Microbiol Date: 2008-12-17 Impact factor: 3.605

Mechanism of conversion of the salmonella O antigen by bacteriophageepsilon 34.

1. Characterization of a polyisoprenoid compound functional in O-antigen biosynthesis.

2. Properties of the O-specific hapten formed in vivo by mutant strains of Salmonella typhimurium.

3. Isolation, purification, and properties of the lipid-linked intermediates of O-antigen biosynthesis.

4. Mechanism of epsilon-15 conversion studies with bacteriphage mutants.

5. Biosynthesis of bacterial lipopolysaccharide. V. Lipid-linked intermediates in the biosynthesis of the O-antigen groups of Salmonella typhimurium.

6. A lipid intermediate in mannan biosynthesis in yeast.

7. Structure of a lipid intermediate in cell wall peptidoglycan synthesis: a derivative of a C55 isoprenoid alcohol.

8. The biosynthesis of mannosyl-1-phosphoryl-polyisoprenol in Micrococcus lysodeikticus and its role in mannan synthesis.

9. Evidence for an intermediate stage in the biosynthesis of the Salmonella O-antigen.

10. Biosynthesis of the determinant 34 of the Salmonella O-antigen.

Review 1. Lipopolysaccharide endotoxins.

Review 2. Bacteriophage control of bacterial virulence.

Review 3. Lipopolysaccharide O-antigens-bacterial glycans made to measure.

4. Formation of polyisoprenol phosphate glucose in Shigella flexneri.

5. The role of lipid-linked activated sugars in glycosylation reactions.

Review 6. Role of lipids in the biosynthesis of the bacterial cell envelope.

7. Role of a sugar-lipid intermediate in colanic acid synthesis by Escherichia coli.

8. Biosynthesis of glucosyl monophosphoryl undecaprenol and its role in lipoteichoic acid biosynthesis.

9. Identification of four genes involved in the lysogenic pathway of the Salmonella newington bacterial virus epsilon 34.

10. Genomic analysis of bacteriophage epsilon 34 of Salmonella enterica serovar Anatum (15+).