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Literature DB >> 5541533

Recovery from N-hydroxyurethan-induced death.

Abstract

Bacteria (Escherichia coli) can recover from the lethal action of N-hydroxyurethan when they are incubated in drug-free liquid medium. This recovery, which is dependent upon energy metabolism, does not occur on solid medium. Recovery is accompanied by repair of the cellular deoxyribonucleic acid (DNA). A bacterial mutant deficient in DNA polymerase was extremely sensitive to the lethal action of hydroxyurethan. Data are presented which support the concept that DNA replication and DNA repair are mediated by different enzymes and that only the former process is inhibited by hydroxyurea.

Entities: Chemical Disease Species

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Year: 1971 PMID： 5541533 PMCID： PMC248423 DOI： 10.1128/jb.105.2.565-572.1971

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

21 in total

1. PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS.

Authors: D NATHANS
Journal: Proc Natl Acad Sci U S A Date: 1964-04 Impact factor: 11.205

2. THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM.

Authors: R B SETLOW; W L CARRIER
Journal: Proc Natl Acad Sci U S A Date: 1964-02 Impact factor: 11.205

3. The assimilation of amino-acids by bacteria. XV. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus.

Authors: E F GALE; J P FOLKES
Journal: Biochem J Date: 1953-02 Impact factor: 3.857

4. On the Relation between Assimilation and Respiration in Suspensions and in Cultures of Escherichia coli.

Authors: C E Clifton; W A Logan
Journal: J Bacteriol Date: 1939-05 Impact factor: 3.490

5. Glucose requirement for DNA breakdown resulting from treatment of Bacillus subtilis with ultraviolet radiation or methyl methanesulfonate.

Authors: T Searashi; B Strauss
Journal: Mutat Res Date: 1967 May-Jun Impact factor: 2.433

6. Effects of N-hydroxyurethan on viability and metabolism of Escherichia coli.

Authors: K P Mullinix; H S Rosenkranz
Journal: J Bacteriol Date: 1971-02 Impact factor: 3.490

7. Saturation of dark repair synthesis: accumulation of strand breaks.

Authors: P Achey; D Billen
Journal: Biophys J Date: 1969-05 Impact factor: 4.033

8. Effects of ultraviolet radiation on macromolecular synthesis in Escherichia coli.

Authors: P A Swenson; R B Setlow
Journal: J Mol Biol Date: 1966-01 Impact factor: 5.469

9. Acylation of cystosine by ethyl N-hydroxycarbamate and its acyl derivatives and the binding of these agents to nucleic acids and proteins.

Authors: R Nery
Journal: J Chem Soc Perkin 1 Date: 1969

Recovery from N-hydroxyurethan-induced death.

1. PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS.

2. THE DISAPPEARANCE OF THYMINE DIMERS FROM DNA: AN ERROR-CORRECTING MECHANISM.

3. The assimilation of amino-acids by bacteria. XV. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus.

4. On the Relation between Assimilation and Respiration in Suspensions and in Cultures of Escherichia coli.

5. Glucose requirement for DNA breakdown resulting from treatment of Bacillus subtilis with ultraviolet radiation or methyl methanesulfonate.

6. Effects of N-hydroxyurethan on viability and metabolism of Escherichia coli.

7. Saturation of dark repair synthesis: accumulation of strand breaks.

8. Effects of ultraviolet radiation on macromolecular synthesis in Escherichia coli.

9. Acylation of cystosine by ethyl N-hydroxycarbamate and its acyl derivatives and the binding of these agents to nucleic acids and proteins.

10. PHENETHYL ALCOHOL. I. EFFECT ON MACROMOLECULAR SYNTHESIS OF ESCHERICHIA COLI.

1. Single-strand breakage in DNA of Escherichia coli exposed to Cd2+.

2. Effects of N-hydroxyurethan on viability and metabolism of Escherichia coli.

3. Molecular mechanisms of accommodation in Escherichia coli to toxic levels of Cd2+.

4. Characterization of the repair of injury induced by freezing Salmonella anatum.

5. Metabolic process during the repair of freeze-injury in Escherichia coli.

6. An effect of hydroxyurea on Staphylococcus epidermidis: temporary loss of viability.