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Literature DB >> 4891791

Saturation of dark repair synthesis: accumulation of strand breaks.

Abstract

Reversal of ultraviolet light damage to DNA by the dark repair system is limited. Experiments utilizing density and radioactive labels demonstrated that repair synthesis is not proportional to dose at doses above 200 ergs/mm(2). In addition, the number of residual excision induced gaps in Escherichia coli B/r hcr(+) DNA increases with higher UV doses. The extent of repair is apparently limited by saturation of the repair synthesis step.

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Year: 1969 PMID： 4891791 PMCID： PMC1367745 DOI： 10.1016/S0006-3495(69)86409-X

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

3 in total

1. Influence of anoxia on radiation-induced breaks in the Escherichia coli chromosome.

Authors: P M Achey; V G Whitfield
Journal: J Bacteriol Date: 1968-03 Impact factor: 3.490

2. Deoxyribonucleic acid repair replication after ultraviolet light or x-ray exposure of bacteria.

Authors: D Billen; R R Hewitt; T Lapthisophon; P M Achey
Journal: J Bacteriol Date: 1967-11 Impact factor: 3.490

3. Reconstruction in vivo of irradiated Escherichia coli deoxyribonucleic acid; the rejoining of broken pieces.

Authors: R A McGrath; R W Williams
Journal: Nature Date: 1966-10-29 Impact factor: 49.962

3 in total

9 in total

1. Relation between survival and deoxyribonucleic acid replication in ultraviolet-irradiated resistant and sensitive strains of Escherichia coli B-r.

Authors: J M Rudé; C O Doudney
Journal: J Bacteriol Date: 1973-03 Impact factor: 3.490

2. Evidence for the control by exrA and polA genes of two branches of the uvr gene-dependent excision repair pathway in Escherichia coli K-12.

Authors: D A Youngs; K C Smith
Journal: J Bacteriol Date: 1973-10 Impact factor: 3.490

8. The involvement of DNA polymerase I in the postreplication repair of ultraviolet radiation-induced damage in Escherichia coli K-12.

Authors: T R Barfknecht; K C Smith
Journal: Mol Gen Genet Date: 1978-11-16

9. Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: incision of ultraviolet-irradiated deoxyribonucleic acid in vivo.

Authors: R J Reynolds; E C Friedberg
Journal: J Bacteriol Date: 1981-05 Impact factor: 3.490

9 in total

Saturation of dark repair synthesis: accumulation of strand breaks.

1. Influence of anoxia on radiation-induced breaks in the Escherichia coli chromosome.

2. Deoxyribonucleic acid repair replication after ultraviolet light or x-ray exposure of bacteria.

3. Reconstruction in vivo of irradiated Escherichia coli deoxyribonucleic acid; the rejoining of broken pieces.

1. Relation between survival and deoxyribonucleic acid replication in ultraviolet-irradiated resistant and sensitive strains of Escherichia coli B-r.

2. Evidence for the control by exrA and polA genes of two branches of the uvr gene-dependent excision repair pathway in Escherichia coli K-12.

3. Characterization of excision repair in Neurospora crassa.

4. Genetic analysis of repair of ultraviolet damage by competent and noncompetent cells of Bacillus subtilis.

5. Recovery from N-hydroxyurethan-induced death.

6. DNA synthesis in Escherichia coli B/r after UV-irradiation.

7. Pyrimidine dimer excision in a Bacillus subtilis Uvr- mutant.

8. The involvement of DNA polymerase I in the postreplication repair of ultraviolet radiation-induced damage in Escherichia coli K-12.

9. Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: incision of ultraviolet-irradiated deoxyribonucleic acid in vivo.