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Literature DB >> 5529745

Cytotoxicity: specificity after in vitro sensitization.

Abstract

Animals sensitized in vivo against an allogeneic tissue subsequently show accelerated rejection specificially of that or antigenically similar tissues. Lymphocytes sensitized in vitro will destroy target cells isogeneic with the sensitizing cells. Lymphocytes sensitized in vitro can differentiate specifically between different allogeneic target cells-as occurs in vivo.

Entities: Disease

Mesh：

Substances：
Chromium Isotopes

Year: 1970 PMID： 5529745 DOI： 10.1126/science.170.3965.1406

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

11 in total

1. Cell-mediated lympholysis in vitro. Independence of mixed lymphocyte reactions and T-cell mitogen responses from the in vitro generation of cytotoxic effectors in primary immunodeficiency diseases.

Authors: C Mawas; M Sasportes; D Charmot; Y Christen; J Dausset
Journal: Clin Exp Immunol Date: 1975-04 Impact factor: 4.330

2. The antibody-dependent cell-mediated cytotoxic reaction. I. The morphological and functional heterogeneity of the rabbit cytotoxic cells.

Authors: M A Keaney; H Hirte; S McPhail; L Fernando; R Belanger; M Richter
Journal: Immunology Date: 1979-12 Impact factor: 7.397

3. The interaction of normal lymphocytes and cells from lymphoid cell lines. VI. Line-directed cytotoxic specificity of lymphocytes activated by autochthonous or allogeneic LCL cells.

Authors: C M Steel; D A Hardy; N R Ling; I J Lauder
Journal: Immunology Date: 1974-05 Impact factor: 7.397

Cytotoxicity: specificity after in vitro sensitization.

1. Cell-mediated lympholysis in vitro. Independence of mixed lymphocyte reactions and T-cell mitogen responses from the in vitro generation of cytotoxic effectors in primary immunodeficiency diseases.

2. The antibody-dependent cell-mediated cytotoxic reaction. I. The morphological and functional heterogeneity of the rabbit cytotoxic cells.

3. The interaction of normal lymphocytes and cells from lymphoid cell lines. VI. Line-directed cytotoxic specificity of lymphocytes activated by autochthonous or allogeneic LCL cells.

4. [Mixed leukocyte culture for immunological donor selection].

5. Factors affecting the autologous mixed lymphocyte reaction in kidney transplantation.

6. Immunological responsiveness of frozen-thawed human lymphocytes.

7. Blastogenic suppression and alloantibody activity of sera from renal allograft recipients.

8. Long-term study of vascularized free-draining intraperitoneal pancreatic segmental allografts in beagle dogs.

9. Allogeneic and xenogeneic response in mixed leukocyte cultures.

10. The immunology of experimental Chagas' disease. 3. Rejection of allogeneic heart cells in vitro.