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Literature DB >> 5504372

A rapid whole blood solubility test to differentiate the sickle-cell trait from sickle-cell anaemia.

R G Huntsman, G P Barclay, D M Canning, G I Yawson.

Abstract

A simple and rapid screening test which differentiates sickle-cell trait and sickle-cell anaemia is described. The test utilizes 0.1 ml of whole blood and is based on the low solubility of reduced sickle haemoglobin. Results intermediate between the sickle-cell trait and sickle-cell anaemia are obtained in unusual cases of sickle-cell anaemia with high foetal haemoglobin. The need to supplement the results with haematological and electrophoretic techniques is discusses.

Entities: Disease

Mesh：

Year: 1970 PMID： 5504372 PMCID： PMC476897 DOI： 10.1136/jcp.23.9.781

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

5 in total

1. The ferrohemoglobin solubility test; its accuracy and precision together with values found in the presence of some abnormal hemoglobins.

Authors: C A GOLDBERG
Journal: Clin Chem Date: 1958-04 Impact factor: 8.327

2. Solubilities of naturally occurring mixtures of human hemoglobin.

Authors: H A ITANO
Journal: Arch Biochem Biophys Date: 1953-11 Impact factor: 4.013

3. A new solubility test for rapid detection of hemoglobin S.

Authors: W P Loh
Journal: J Indiana State Med Assoc Date: 1968-12

4. Sickling tests. Pitfalls in performance and interpretation.

Authors: R G Schneider; J B Alperin; H Lehmann
Journal: JAMA Date: 1967-10-30 Impact factor: 56.272

5. Relatively benign sickle-cell anaemia in 60 patients aged over 30 in the West Indies.

Authors: G R Serjeant; R Richards; P R Barbor; P F Milner
Journal: Br Med J Date: 1968-07-13

5 in total

15 in total

1. Detection of sickle cell hemoglobin in Haiti by genotyping and hemoglobin solubility tests.

Authors: Tamar E Carter; Michael von Fricken; Jean R Romain; Gladys Memnon; Yves St Victor; Laura Schick; Bernard A Okech; Connie J Mulligan
Journal: Am J Trop Med Hyg Date: 2014-06-23 Impact factor: 2.345

Review 2. The pressing need for point-of-care diagnostics for sickle cell disease: A review of current and future technologies.

Authors: Patrick T McGann; Carolyn Hoppe
Journal: Blood Cells Mol Dis Date: 2017-08-08 Impact factor: 3.039

10. Antenatal screening for identification of couples for prenatal diagnosis of severe hemoglobinopathies in surat, South gujarat.

Authors: Dipal S Bhukhanvala; Smita M Sorathiya; Pratibha Sawant; Roshan Colah; Kanjaksha Ghosh; Snehalata C Gupte
Journal: J Obstet Gynaecol India Date: 2012-11-02

A rapid whole blood solubility test to differentiate the sickle-cell trait from sickle-cell anaemia.

1. The ferrohemoglobin solubility test; its accuracy and precision together with values found in the presence of some abnormal hemoglobins.

2. Solubilities of naturally occurring mixtures of human hemoglobin.

3. A new solubility test for rapid detection of hemoglobin S.

4. Sickling tests. Pitfalls in performance and interpretation.

5. Relatively benign sickle-cell anaemia in 60 patients aged over 30 in the West Indies.

1. Detection of sickle cell hemoglobin in Haiti by genotyping and hemoglobin solubility tests.

Review 2. The pressing need for point-of-care diagnostics for sickle cell disease: A review of current and future technologies.

3. An economic high speed electrophoretic screening system for hemoglobin S and other proteins.

4. Reliability and modification of Sickledex test.

5. Automated mass screening for hemoglobin S: a rational method.

6. Detecting sickle haemoglobin.

7. Detecting sickle hemoglobin.

8. An improved solubility test for haemoglobin S.

9. An automated screening technique for the detection of sickle-cell haemoglobin.

10. Antenatal screening for identification of couples for prenatal diagnosis of severe hemoglobinopathies in surat, South gujarat.