Literature DB >> 5478194

Parkinson's disease: activity of L-dopa decarboxylase in discrete brain regions.

K Lloyd, O Hornykiewicz.   

Abstract

The activity of L-dopa decarboxylase was greatly reduced in the striatum, less so in the hypothalamus, and unchanged in the cortex of brains of patients with Parkinson's disease. However, it appears that even in the striatum enough activity remained to allow for the formation of dopamine from L-dopa in patients treated with large doses of L-dopa.

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Year:  1970        PMID： 5478194     DOI： 10.1126/science.170.3963.1212

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  34 in total

1.  L-Dopa decarboxylase expression profile in human cancer cells.

Authors:  Ioanna Chalatsa; Eleftheria Nikolouzou; Emmanuel G Fragoulis; Dido Vassilacopoulou
Journal:  Mol Biol Rep       Date:  2010-06-11       Impact factor: 2.316

Review 2.  Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa.

Authors:  Yoland Smith; Thomas Wichmann; Stewart A Factor; Mahlon R DeLong
Journal:  Neuropsychopharmacology       Date:  2011-09-28       Impact factor: 7.853

Review 3.  The blood-brain barrier: bottleneck in brain drug development.

Authors:  William M Pardridge
Journal:  NeuroRx       Date:  2005-01

4.  Release of membrane-associated L-dopa decarboxylase from human cells.

Authors:  Ioanna Chalatsa; Emmanuel G Fragoulis; Dido Vassilacopoulou
Journal:  Neurochem Res       Date:  2011-04-11       Impact factor: 3.996

Review 5.  Animal models of Parkinson's disease: an empirical comparison with the phenomenology of the disease in man.

Authors:  M Gerlach; P Riederer
Journal:  J Neural Transm (Vienna)       Date:  1996       Impact factor: 3.575

Review 6.  Multisite intracerebral microdialysis to study the mechanism of L-DOPA induced dopamine and serotonin release in the parkinsonian brain.

Authors:  S Navailles; M Lagière; A Contini; P De Deurwaerdère
Journal:  ACS Chem Neurosci       Date:  2013-04-15       Impact factor: 4.418

7.  The effect of low dose carbidopa/levodopa on prolactin and growth hormone concentrations in patients with breast cancer and in benign breast tumours.

Authors:  M K Jones; I D Ramsay; P G Jenner
Journal:  Br J Clin Pharmacol       Date:  1978-05       Impact factor: 4.335

8.  Central catecholamine metabolism in vivo and the cognitive and motor deficits in Parkinson's disease.

Authors:  J J Mann; M Stanley; R D Kaplan; J Sweeney; A Neophytides
Journal:  J Neurol Neurosurg Psychiatry       Date:  1983-10       Impact factor: 10.154

9.  The nigrostriatal dopaminergic pathway in Wilson's disease studied with positron emission tomography.

Authors:  B J Snow; M Bhatt; W R Martin; D Li; D B Calne
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-01       Impact factor: 10.154

10.  Genomic organization of the rat aromatic L-amino acid decarboxylase (AADC) locus: partial analysis reveals divergence from the Drosophila dopa decarboxylase (DDC) gene structure.

Authors:  S L Hahn; M Hahn; T H Joh
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957
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