Literature DB >> 23541043

Multisite intracerebral microdialysis to study the mechanism of L-DOPA induced dopamine and serotonin release in the parkinsonian brain.

S Navailles1, M Lagière, A Contini, P De Deurwaerdère.   

Abstract

L-DOPA is currently one of the best medications for Parkinson's disease. It was assumed for several years that its benefits and side effects were related to the enhancement of dopamine release in the dopamine-depleted striatum. The use of intracerebral microdialysis combined with a pharmacological approach has led to the discovery that serotonergic neurons are responsible for dopamine release induced by L-DOPA. The subsequent use of multisite microdialysis has further revealed that L-DOPA-stimulated dopamine release is widespread and related to the serotonergic innervation. The present Review emphasizes the functional impact of extrastriatal release of dopamine induced by L-DOPA in both the therapeutic and side effects of L-DOPA.

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Year:  2013        PMID： 23541043      PMCID： PMC3656765          DOI： 10.1021/cn400046e

Source DB:  PubMed          Journal:  ACS Chem Neurosci        ISSN： 1948-7193            Impact factor:   4.418


  132 in total

Review 1.  L-DOPA and serotonergic neurons: functional implication and therapeutic perspectives in Parkinson's disease.

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Authors:  Karen L Eskow Jaunarajs; Kristin B Dupre; Corinne Y Ostock; Thomas Button; Terrence Deak; Christopher Bishop
Journal:  Behav Pharmacol       Date:  2010-10       Impact factor: 2.293

Review 3.  A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence.

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Authors:  Yuexiang Wang; Adrian C Michael
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5.  Biotransformation of locally applied precursors of dopamine, serotonin and noradrenaline in striatum and hippocampus: a microdialysis study.

Authors:  S Sarre; I Smolders; K Thorré; G Ebinger; Y Michotte
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6.  Levodopa treatment improves functional recovery after experimental stroke.

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Journal:  Stroke       Date:  2011-11-17       Impact factor: 7.914

7.  Serotonergic neurons mediate ectopic release of dopamine induced by L-DOPA in a rat model of Parkinson's disease.

Authors:  Sylvia Navailles; Bernard Bioulac; Christian Gross; Philippe De Deurwaerdère
Journal:  Neurobiol Dis       Date:  2010-01-22       Impact factor: 5.996

Review 8.  Dopamine (3-hydroxytyramine) and brain function.

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Journal:  Synapse       Date:  1987       Impact factor: 2.562

10.  Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats.

Authors:  C Marin; E Aguilar; M C Rodríguez-Oroz; G D Bartoszyk; J A Obeso
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  11 in total

Review 1.  Presynaptic effects of levodopa and their possible role in dyskinesia.

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Review 2.  Catecholamine/Serotonin interactions: systems thinking for brain function and disease.

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Review 3.  The serotonergic system in L-DOPA-induced dyskinesia: pre-clinical evidence and clinical perspective.

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5.  Selective loss of bi-directional synaptic plasticity in the direct and indirect striatal output pathways accompanies generation of parkinsonism and l-DOPA induced dyskinesia in mouse models.

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6.  NIR Biosensing of Neurotransmitters in Stem Cell-Derived Neural Interface Using Advanced Core-Shell Upconversion Nanoparticles.

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Review 7.  Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson's disease.

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Review 8.  Brain morphometry and the neurobiology of levodopa-induced dyskinesias: current knowledge and future potential for translational pre-clinical neuroimaging studies.

Authors:  Clare J Finlay; Susan Duty; Anthony C Vernon
Journal:  Front Neurol       Date:  2014-06-12       Impact factor: 4.003

9.  The acute and long-term L-DOPA effects are independent from changes in the activity of dorsal raphe serotonergic neurons in 6-OHDA lesioned rats.

Authors:  C Miguelez; S Navailles; P De Deurwaerdère; L Ugedo
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Review 10.  L-DOPA in Parkinson's Disease: Looking at the "False" Neurotransmitters and Their Meaning.

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