Literature DB >> 5461364

Hyperphenylalaninemia: disaggregation of brain polyribosomes in young rats.

K Aoki, F L Siegel.   

Abstract

A single injection of l-phenzylalanine in 7-day-old rats produtced disaggregation of brain polyribosomties and inhibition of in vitro protein synthesis in cell-free systems prepared from brain. Liver polyribosomes and in vitro protein synthesis in hepatic systems were not affected. In 4-week-old rats these effects on brain protein synthesis did not occur.

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Year:  1970        PMID： 5461364     DOI： 10.1126/science.168.3927.129

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

1.  The mechanism of polyribosome disaggregation in brain tissue by phenylalanine.

Authors:  F Taub; T C Johnson
Journal:  Biochem J       Date:  1975-10       Impact factor: 3.857

2.  The effects of hyperphenylalaninaemia on the concentrations of aminoacyl-transfer ribonucleic acid in vivo. A mechanism for the inhibition of neural protein synthesis by phenylalanine.

Authors:  J V Hughes; T C Johnson
Journal:  Biochem J       Date:  1977-03-15       Impact factor: 3.857

3.  Abnormal amino acid metabolism and brain protein synthesis during neural development.

Authors:  J V Hughes; T C Johnson
Journal:  Neurochem Res       Date:  1978-08       Impact factor: 3.996

4.  In vitro localization of the protein synthesis defect associated with experimental phenylketonuria.

Authors:  M A Elsliger; G R Thériault; D Gauthier
Journal:  Neurochem Res       Date:  1989-01       Impact factor: 3.996

5.  [Amino acid imbalance as a pathogenetic factor in mental retardation (author's transl)].

Authors:  G Fekete
Journal:  Klin Wochenschr       Date:  1974-05-15

6.  Cerebral ribosomal protein phosphorylation in experimental hyperphenylalaninaemia.

Authors:  S Roberts; B S Morelos
Journal:  Biochem J       Date:  1980-08-15       Impact factor: 3.857

7.  Preparation of a cell-free extract from rat brain which can initiate protein synthesis in vitro.

Authors:  J W Cosgrove; S I Rapoport
Journal:  Neurochem Res       Date:  1986-09       Impact factor: 3.996

8.  The effect of elevated plasma phenylalanine levels on protein synthesis rates in adult rat brain.

Authors:  D S Dunlop; X R Yang; A Lajtha
Journal:  Biochem J       Date:  1994-09-01       Impact factor: 3.857

9.  Utilization of tyrosine and tryptophan for protein synthesis by undernourished developing rat brain.

Authors:  S Kalyanasundaram; P S Ramanamurthy
Journal:  Neurochem Res       Date:  1983-11       Impact factor: 3.996

10.  Neuronal degeneration in the brain of the brindled mouse. An ultrastructural study of the cerebral cortical neurons.

Authors:  K Yajima; K Suzuki
Journal:  Acta Neuropathol       Date:  1979-01-12       Impact factor: 17.088
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