Literature DB >> 5461272

Alkaloids from catecholamines in adrenal tissue: possible role in alcoholism.

G Cohen, M Collins.   

Abstract

Epinephrine and norepinephrine condensed with acetaldehyde or with formaldehyde in dilute aqueous solution at neutral pH and room temperature to form 1,2,3,4-tetrahydroiso-quinoline alkaloids. Similar condensation reactions occurred in cow adrenal glands perfused with dilute aldehyde solutions at 37 degrees C. Biosynthesis of these alkaloids in vivo could play a role in altering an individual's behavior during and after the ingestion of alcohol.

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Year:  1970        PMID： 5461272     DOI： 10.1126/science.167.3926.1749

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  38 in total

1.  Preparation and pharmacological activity of the condensation product of adrenaline with acetaldehyde.

Authors:  W Osswald; J Polónia; M A Polónia
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1975       Impact factor: 3.000

2.  [Chemical mechanism of the effect of alcohol].

Authors:  G Bringmann
Journal:  Naturwissenschaften       Date:  1979-01

3.  Analgesic effects of 3-carboxysalsolinol alone and in combination with morphine.

Authors:  A Marshall; M Hirst; K Blum
Journal:  Experientia       Date:  1977-06-15

4.  Fifty Years in the Development of a Glutaminergic-Dopaminergic Optimization Complex (KB220) to Balance Brain Reward Circuitry in Reward Deficiency Syndrome: A Pictorial.

Authors:  K Blum; M Febo; R D Badgaiyan
Journal:  Austin Addict Sci       Date:  2016-10-12

Review 5.  Understanding the Scientific Basis of Post-traumatic Stress Disorder (PTSD): Precision Behavioral Management Overrides Stigmatization.

Authors:  Kenneth Blum; M C Gondré-Lewis; E J Modestino; L Lott; D Baron; D Siwicki; T McLaughlin; A Howeedy; M H Krengel; M Oscar-Berman; P K Thanos; I Elman; M Hauser; L Fried; A Bowirrat; R D Badgaiyan
Journal:  Mol Neurobiol       Date:  2019-05-23       Impact factor: 5.590

Review 6.  Dopamine and disease.

Authors:  A Barbeau
Journal:  Can Med Assoc J       Date:  1970-10-17       Impact factor: 8.262

7.  Oxidation of vanillin by cream xanthine oxidase and its inhibition by allopurinol.

Authors:  R Fried
Journal:  Experientia       Date:  1971-02-15

8.  Protective action of ascorbic acid and sulfur compounds against acetaldehyde toxicity: implications in alcoholism and smoking.

Authors:  H Sprince; C M Parker; G G Smith; L J Gonzales
Journal:  Agents Actions       Date:  1975-05

9.  Locomotor stimulant effects of acute and repeated intrategmental injections of salsolinol in rats: role of mu-opioid receptors.

Authors:  Lucía Hipólito; María-José Sánchez-Catalán; Teodoro Zornoza; Ana Polache; Luis Granero
Journal:  Psychopharmacology (Berl)       Date:  2010-03       Impact factor: 4.530

10.  Ethanol and tetrahydroisoquinoline alkaloids do not produce narcotic discriminative stimulus effects.

Authors:  G T Shearman; A Herz
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530
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