Literature DB >> 5451955

Simple method for determining isoniazid acetylator phenotype.

D W Russell.   

Abstract

Methods have been developed for estimating acetylisoniazid and isoniazid in urine without a spectrophotometer. In experiments with volunteers the ratio of acetylisoniazid to isoniazid in urine samples collected the morning after three spaced oral doses each of 100 mg. was bimodally distributed.

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Year:  1970        PMID： 5451955      PMCID： PMC1701511          DOI： 10.1136/bmj.3.5718.324

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  10 in total

1.  HUMAN ACETYLATION POLYMORPHISM.

Authors:  D A EVANS; T A WHITE
Journal:  J Lab Clin Med       Date:  1964-03

2.  STUDIES ON PHARMACOGENETICS. I. THE ENZYMIC ACETYLATION OF ISONICOTINIC ACID HYDRAZIDE (INH).

Authors:  H W GOEDDE; E SCHOEPF; D FLEISCHMANN
Journal:  Biochem Pharmacol       Date:  1964-12       Impact factor: 5.858

3.  THE RELATIONSHIP BETWEEN THE CAPACITIES OF HUMAN SUBJECTS TO ACETYLATE ISONIAZID, SULFANILAMIDE AND SULFAMETHAZINE.

Authors:  J H PETERS; G R GORDON; P BROWN
Journal:  Life Sci (1962)       Date:  1965-01

4.  Comparison of isoniazid concentrations in the blood of people of Japanese and European descent; therapeutic and genetic implications.

Authors:  H W HARRIS; R A KNIGHT; M J SELIN
Journal:  Am Rev Tuberc       Date:  1958-12

5.  Genetic control of isoniazid metabolism in man.

Authors:  D A EVANS; K A MANLEY; V A McKUSICK
Journal:  Br Med J       Date:  1960-08-13

6.  Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis.

Authors:  H B HUGHES; J P BIEHL; A P JONES; L H SCHMIDT
Journal:  Am Rev Tuberc       Date:  1954-08

7.  An improved and simplified method of detecting the acetylator phenotype.

Authors:  D A Evans
Journal:  J Med Genet       Date:  1969-12       Impact factor: 6.318

8.  Method for the estimation of acetylisoniazid in urine.

Authors:  P Venkataraman; L Eidus; S P Tripathy
Journal:  Tubercle       Date:  1968-06

9.  Rapid determination of isonicotinic acid hydrazide in whole blood with 2,4,6-trinitrobenzenesulphonic acid.

Authors:  L C Dymond; D W Russell
Journal:  Clin Chim Acta       Date:  1970-03       Impact factor: 3.786

10.  Isoniazid and ethionamide serum levels and inactivation in Finnish subjects.

Authors:  H Tiitinen
Journal:  Scand J Respir Dis       Date:  1969
  10 in total
  6 in total

1.  Simplified method for determining acetylator phenotype.

Authors:  H Schröder
Journal:  Br Med J       Date:  1972-08-26

2.  Screening of isoniazid inactivators.

Authors:  L Eidus; M M Hodgkin
Journal:  Antimicrob Agents Chemother       Date:  1973-01       Impact factor: 5.191

3.  Simplified isoniazid acetylator phenotyping.

Authors:  D W Russell; L Eidus
Journal:  Can Med Assoc J       Date:  1972-06-10       Impact factor: 8.262

4.  Inactivation of isoniazid by Canadian Eskimos and Indians.

Authors:  C W Jeanes; O Schaefer; L Eidus
Journal:  Can Med Assoc J       Date:  1972-02-19       Impact factor: 8.262

5.  Isoniazid acetylation rates (phenotypes) of patients being treated for tuberculosis.

Authors:  E Mason; D W Russell
Journal:  Bull World Health Organ       Date:  1971       Impact factor: 9.408

6.  Determination of the acetylator phenotype and pharmacokinetics of some sulphonamides in man.

Authors:  T B Vree; W J O'Reilly; Y A Hekster; J E Damsma; E van der Kleijn
Journal:  Clin Pharmacokinet       Date:  1980 May-Jun       Impact factor: 6.447
  6 in total

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