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Literature DB >> 4403571

Simplified method for determining acetylator phenotype.

Abstract

A chemical method has been developed for estimating the acetylator phenotype without the use of special equipment. One urine specimen taken after ingestion of sulphadimidine, sulphapyridine, or sulphasalazine is required. The acetylator phenotype was assessed correctly in 150 urine specimens from 100 healthy subjects. Between 15 and 25 specimens can be determined hourly. Urine specimens for the test can be stored for two weeks at 37 degrees C without any loss of drugs or their metabolites.

Entities: Chemical

Mesh：

Substances：

Year: 1972 PMID： 4403571 PMCID： PMC1785779 DOI： 10.1136/bmj.3.5825.506

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

9 in total

1. HUMAN ACETYLATION POLYMORPHISM.

Authors: D A EVANS; T A WHITE
Journal: J Lab Clin Med Date: 1964-03

2. The polymorphic acetylation of sulphapyridine in man.

Authors: H Schröder; D A Evans
Journal: J Med Genet Date: 1972-06 Impact factor: 6.318

3. The use of the autoanalyzer to determine the acetylator phenotype.

Authors: L C Eze; D A Evans
Journal: J Med Genet Date: 1972-03 Impact factor: 6.318

4. An improved and simplified method of detecting the acetylator phenotype.

Authors: D A Evans
Journal: J Med Genet Date: 1969-12 Impact factor: 6.318

5. Diphenylhydantoin intoxication. A complication of isoniazid therapy.

Authors: H Kutt; R Brennan; H Dehejia; K Verebely
Journal: Am Rev Respir Dis Date: 1970-03

6. Simple method for determining isoniazid acetylator phenotype.

Authors: D W Russell
Journal: Br Med J Date: 1970-08-08

7. Isoniazid and ethionamide serum levels and inactivation in Finnish subjects.

Authors: H Tiitinen
Journal: Scand J Respir Dis Date: 1969

8. The polymorphic acetylation of dapsone in man.

Authors: R Gelber; J H Peters; G R Gordon; A J Glazko; L Levy
Journal: Clin Pharmacol Ther Date: 1971 Mar-Apr Impact factor: 6.875

9. Sulphadimidine acetylation test for classification of patients as slow or rapid inactivators of isoniazid.

Authors: K V Rao; D A Mitchison; N G Nair; K Prema; S P Tripathy
Journal: Br Med J Date: 1970-08-29

9 in total

31 in total

1. The relationship between acetylator status and inhibition of monoamine oxidase, excretion of free drug and antidepressant response in depressed patients on phenelzine.

Authors: E C Johnstone
Journal: Psychopharmacologia Date: 1976-04-15

2. Acetylator phenotype and the clinical pharmacology of slow-release procainamide.

Authors: W Campbell; W J Tilstone; D H Lawson; I Hutton; T D Lawrie
Journal: Br J Clin Pharmacol Date: 1976-12 Impact factor: 4.335

Review 3. Survey of the human acetylator polymorphism in spontaneous disorders.

Authors: D A Evans
Journal: J Med Genet Date: 1984-08 Impact factor: 6.318

4. Metabolism of procainamide in patients with chronic heart failure, chronic respiratory failure and chronic renal failure.

Authors: P du Souich; S Erill
Journal: Eur J Clin Pharmacol Date: 1978-11-09 Impact factor: 2.953

5. Contribution of atenolol, bendrofluazide, and hydrallazine to management of severe hypertension.

Authors: R G Wilcox; J R Mitchell
Journal: Br Med J Date: 1977-08-27

6. Polymorphic acetylation: lack of influence of rheumatic disease activity and concomitant drug administration.

Authors: C Astbury; C Beyeler; H A Bird
Journal: Rheumatol Int Date: 1995 Impact factor: 2.631

7. Acute effects of prizidilol on blood pressure, heart rate, catecholamines, renin and aldosterone in essential hypertension.

Authors: M G Bianchetti; K Boehringer; P Weidmann; L Link; H Schiffl; W H Ziegler
Journal: Eur J Clin Pharmacol Date: 1982-10 Impact factor: 2.953