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Literature DB >> 5445688

The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle.

Abstract

1. Tetramisole (100 mug/ml) paralysed live Ascaris in 3 min.2. Tetramisole (10 mug/ml) caused a sustained contraction of the isolated somatic muscles of the worm. This contraction was not blocked by curare nor by piperazine.3. Tetramisole reduced the resting potential of Ascaris muscle from 34+/-4 to 10+/-1 mV.4. Tetramisole caused contraction of Ascaris muscle previously depolarized with high K(+) solutions. This observation suggests that tetramisole can induce a contracture that is independent of membrane depolarization.

Entities: Chemical Disease

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Year: 1970 PMID： 5445688 PMCID： PMC1702578 DOI： 10.1111/j.1476-5381.1970.tb10601.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

9 in total

1. ELECTROPHYSIOLOGY OF THE SOMATIC MUSCLE CELLS OF ASCARIS LUMBRICOIDES.

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Authors: D H EVANS; H O SCHILD; S THESLEFF
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Authors: G Chaia; A S da Cunha
Journal: Rev Inst Med Trop Sao Paulo Date: 1968 Mar-Apr Impact factor: 1.846

6. Tetramisole (R 8299), a new, potent broad spectrum anthelmintic.

Authors: D Thienpont; O F Vanparijs; A H Raeymaekers; J Vandenberk; J A Demoen; F T Allewijn; R P Marsboom; C J Niemegeers; K H Schellekens; P A Janssen
Journal: Nature Date: 1966-03-12 Impact factor: 49.962

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Authors: L G GOODWIN
Journal: Br J Pharmacol Chemother Date: 1958-06

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Authors: H C Lüttgau; H Oetliker
Journal: J Physiol Date: 1968-01 Impact factor: 5.182

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Authors: J DELCASTILLO; W C DEMELLO; T MORALES
Journal: J Gen Physiol Date: 1964-09 Impact factor: 4.086

9 in total

18 in total

1. Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor.

Authors: Thomas Boulin; Marc Gielen; Janet E Richmond; Daniel C Williams; Pierre Paoletti; Jean-Louis Bessereau
Journal: Proc Natl Acad Sci U S A Date: 2008-11-19 Impact factor: 11.205

2. Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance.

Authors: T Boulin; A Fauvin; C L Charvet; J Cortet; J Cabaret; J-L Bessereau; C Neveu
Journal: Br J Pharmacol Date: 2011-11 Impact factor: 8.739

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Journal: Experientia Date: 1974-11-15

4. Pharmacological characterization of a homomeric nicotinic acetylcholine receptor formed by Ancylostoma caninum ACR-16.

Authors: Shivani Choudhary; James G Tipton; Melanie Abongwa; Matthew T Brewer; Jeba Jesudoss Chelladurai; Nicole Musselman; Richard J Martin; Alan P Robertson
Journal: Invert Neurosci Date: 2019-09-05

5. Basic Caenorhabditis elegans methods: synchronization and observation.

Authors: Montserrat Porta-de-la-Riva; Laura Fontrodona; Alberto Villanueva; Julián Cerón
Journal: J Vis Exp Date: 2012-06-10 Impact factor: 1.355

6. Selective effect of the anthelmintic bephenium on Haemonchus contortus levamisole-sensitive acetylcholine receptors.

Authors: Claude L Charvet; Alan P Robertson; Jacques Cabaret; Richard J Martin; Cédric Neveu
Journal: Invert Neurosci Date: 2012-04-24

7. Effects of the muscarinic agonist, 5-methylfurmethiodide, on contraction and electrophysiology of Ascaris suum muscle.

Authors: Sasa M Trailovic; Saurabh Verma; Cheryl L Clark; Alan P Robertson; Richard J Martin
Journal: Int J Parasitol Date: 2007-12-08 Impact factor: 3.981