Literature DB >> 54345

A clinical trial of intravenous bleomycin in the treatment of brain tumors.

K Takeuchi.   

Abstract

The author has carried out the administration of bleomycin, chiefly by the intravenous route, in the postoperative adjuvant treatment of 150 cases of brain tumor since January 1969. The overall response rate of gliomas to bleomycin was more than 50 per cent. No distinct, given tendency toward possible differences in bleomycin effectiveness due to the type and location of tumors was revealed, but it appears that there were fewer effective cases among highly malignant gliomas and metastitic brain tumors. The survival data also showed encouraging results.

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Year:  1975        PMID: 54345

Source DB:  PubMed          Journal:  Int J Clin Pharmacol Biopharm        ISSN: 0340-0026


  8 in total

Review 1.  Intracavitary therapeutic options in the management of cystic craniopharyngioma.

Authors:  Adrián Cáceres
Journal:  Childs Nerv Syst       Date:  2005-07-19       Impact factor: 1.475

Review 2.  Neuro-oncology index and review (adult primary brain tumors). Radiotherapy, chemotherapy, immunotherapy, photodynamic therapy.

Authors:  M S Mahaley
Journal:  J Neurooncol       Date:  1991-10       Impact factor: 4.130

Review 3.  A critique of the role of the blood-brain barrier in the chemotherapy of human brain tumors.

Authors:  D J Stewart
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130

4.  Statistical analysis of factors affecting survival after glioblastoma multiforme.

Authors:  K Takeuchi; K Hoshino
Journal:  Acta Neurochir (Wien)       Date:  1977       Impact factor: 2.216

5.  A potential application for the intracerebral injection of drugs entrapped within liposomes in the treatment of human cerebral gliomas.

Authors:  R O McKeran; G Firth; S Oliver; D Uttley; S O'Laoire
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-12       Impact factor: 10.154

6.  Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.

Authors:  A B Clarkson; C J Bacchi; G H Mellow; H C Nathan; P P McCann; A Sjoerdsma
Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

7.  Bleomycin and brain tumors. A review.

Authors:  R A Morantz; B F Kimler; T S Vats; S D Henderson
Journal:  J Neurooncol       Date:  1983       Impact factor: 4.130

8.  Prediction of cancer drugs by chemical-chemical interactions.

Authors:  Jing Lu; Guohua Huang; Hai-Peng Li; Kai-Yan Feng; Lei Chen; Ming-Yue Zheng; Yu-Dong Cai
Journal:  PLoS One       Date:  2014-02-03       Impact factor: 3.240

  8 in total

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