Literature DB >> 5411180

Bladder cancer induction by aromatic amines: role of N-hydroxy metabolites.

J L Radomski, E Brill.   

Abstract

Repeated installation of N-hydroxy-2 naphthylamine into dog bladders produced tumors of this organ. There is a correlation of degree of carcinogenicity of 1-naphthylamine, 2-naphthylamine, and 4-aminobiphenyl with both methemoglobin production in the blood and concentration of N-oxidation products in the urine. Thus, N-hydroxylation appears to be the key to bladder cancer production by aromatic amines.

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Year:  1970        PMID： 5411180     DOI： 10.1126/science.167.3920.992

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

1.  Quantification of Hemoglobin and White Blood Cell DNA Adducts of the Tobacco Carcinogens 2-Amino-9H-pyrido[2,3-b]indole and 4-Aminobiphenyl Formed in Humans by Nanoflow Liquid Chromatography/Ion Trap Multistage Mass Spectrometry.

Authors:  Tingting Cai; Medjda Bellamri; Xun Ming; Woon-Puay Koh; Mimi C Yu; Robert J Turesky
Journal:  Chem Res Toxicol       Date:  2017-05-25       Impact factor: 3.739

2.  Species variation in bladder cell and liver cell activation of acetylaminofluorene.

Authors:  R Langenbach; K Rudo; S Ellis; C Hix; S Nesnow
Journal:  Cell Biol Toxicol       Date:  1987-09       Impact factor: 6.691

3.  Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells.

Authors:  Medjda Bellamri; Lihua Yao; Radha Bonala; Francis Johnson; Linda B Von Weymarn; Robert J Turesky
Journal:  Arch Toxicol       Date:  2019-06-15       Impact factor: 5.153

Review 4.  Pharmacologically active metabolites of drugs and other foreign compounds. Clinical, pharmacological, therapeutic and toxicological considerations.

Authors:  D E Drayer
Journal:  Drugs       Date:  1982-12       Impact factor: 9.546

Review 5.  Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines.

Authors:  Robert J Turesky; Loic Le Marchand
Journal:  Chem Res Toxicol       Date:  2011-06-20       Impact factor: 3.739

6.  Genetically determined N-acetylation and oxidation capacities in Japanese patients with non-occupational urinary bladder cancer.

Authors:  Y Horai; K Fujita; T Ishizaki
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

7.  Identification by physical means of organic moieties of conjugates produced from carbaryl by tobacco cells in suspension culture.

Authors:  R K Locke; J Y Chen; J N Damico; L R Dusold; J A Sphon
Journal:  Arch Environ Contam Toxicol       Date:  1976       Impact factor: 2.804

8.  Biomonitoring the cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in canine fur.

Authors:  Dan Gu; Zachary L Neuman; Jaime F Modiano; Robert J Turesky
Journal:  J Agric Food Chem       Date:  2012-08-29       Impact factor: 5.279

9.  Methemoglobin formation and binding to blood constituents as indicators for the formation, availability and reactivity of activated metabolites derived from trans-4-aminostilbene and related aromatic amines.

Authors:  E Wieland; H G Neumann
Journal:  Arch Toxicol       Date:  1978-02-21       Impact factor: 5.153

10.  Activation of aromatic amines to mutagens by bovine bladder and liver cells.

Authors:  L Oglesby; C Hix-Baker; P MacNair; M Sieg; L Snow; R Langenbach
Journal:  Environ Health Perspect       Date:  1983-03       Impact factor: 9.031
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