Literature DB >> 6759093

Pharmacologically active metabolites of drugs and other foreign compounds. Clinical, pharmacological, therapeutic and toxicological considerations.

D E Drayer.   

Abstract

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Year:  1982        PMID： 6759093     DOI： 10.2165/00003495-198224060-00003

Source DB:  PubMed          Journal:  Drugs        ISSN： 0012-6667            Impact factor:   9.546


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  119 in total

Review 1.  Pathways of drug metabolism in man.

Authors:  D E Drayer
Journal:  Med Clin North Am       Date:  1974-09       Impact factor: 5.456

2.  Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites.

Authors:  Z H Israili; S A Cucinell; J Vaught; E Davis; J M Lesser; P G Dayton
Journal:  J Pharmacol Exp Ther       Date:  1973-10       Impact factor: 4.030

3.  3,4-Benzpyrene and aniline are hydroxylated by human fetal liver but not by placenta at 6-7 weeks of fetal age.

Authors:  O Pelkonen; N T Kärki
Journal:  Biochem Pharmacol       Date:  1973-06-15       Impact factor: 5.858

Review 4.  The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation.

Authors:  M Kiese
Journal:  Pharmacol Rev       Date:  1966-09       Impact factor: 25.468

5.  Formation and significance of 6-methylthiopurine ribonucleotide as a metabolite of 6-mercaptopurine.

Authors:  L L Bennett; P W Allan
Journal:  Cancer Res       Date:  1971-02       Impact factor: 12.701

6.  The metabolism of phenacetin in patients with enal diseas.

Authors:  L F Prescott
Journal:  Clin Pharmacol Ther       Date:  1969 May-Jun       Impact factor: 6.875

7.  Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration.

Authors:  B B Gallagher; I P Baumel; R H Mattson
Journal:  Neurology       Date:  1972-11       Impact factor: 9.910

8.  Conversion of cortisone to cortisol and prednisone to prednisolone.

Authors:  J S Jenkins; P A Sampson
Journal:  Br Med J       Date:  1967-04-22

9.  Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice.

Authors:  J Kapitulnik; P G Wislocki; W Levin; H Yagi; D M Jerina; A H Conney
Journal:  Cancer Res       Date:  1978-02       Impact factor: 12.701

10.  Antiarrhythmic efficacy, pharmacokinetics and safety of N-acetylprocainamide in human subjects: comparison with procainamide.

Authors:  D M Roden; S B Reele; S B Higgins; G R Wilkinson; R F Smith; J A Oates; R L Woosley
Journal:  Am J Cardiol       Date:  1980-09       Impact factor: 2.778
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  6 in total

1.  The role of metabolites in bioequivalency assessment. I. Linear pharmacokinetics without first-pass effect.

Authors:  M L Chen; A J Jackson
Journal:  Pharm Res       Date:  1991-01       Impact factor: 4.200

2.  The role of metabolism in the immunogenicity of drugs: production of antibodies to a horseradish peroxidase generated conjugate paracetamol.

Authors:  J Chesham; G E Davies
Journal:  Clin Exp Immunol       Date:  1985-08       Impact factor: 4.330

Review 3.  Formation of active metabolites of psychotropic drugs. An updated review of their significance.

Authors:  S Caccia; S Garattini
Journal:  Clin Pharmacokinet       Date:  1990-06       Impact factor: 6.447

Review 4.  Principles of pharmacotherapy: II. Pharmacokinetics.

Authors:  T J Pallasch
Journal:  Anesth Prog       Date:  1988 Jul-Aug

5.  Drug metabolite concentration-time profiles: influence of route of drug administration.

Authors:  J B Houston; G Taylor
Journal:  Br J Clin Pharmacol       Date:  1984-04       Impact factor: 4.335

6.  Bioequivalence of allopurinol preparations: to be assessed by the parent drug or the active metabolite?

Authors:  I Walter-Sack; J X de Vries; C Kreiner; A Ittensohn; G Stenzhorn; A Voss; E Weber
Journal:  Clin Investig       Date:  1993-03
  6 in total

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