Literature DB >> 538808

The anthelmintic effects of flubendazole on Brugia pahangi.

D A Denham, R Samad, S Y Cho, R R Suswillo, S C Skippins.   

Abstract

The anthelmintic effects of flubendazole (methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl] carbamate) (Janssen Pharmaceutica) were evaluated in jirds (Meriones unguiculatus) and cats (Felis cattus) infected with Brugia pahangi. Flubendazole was macrofilaricidal at 5 x 2.5 mg/kg and 1 x 25 mg/kg in jirds and 1 x 100 mg/kg in cats when administered by subcutaneous injection. It also killed developing larvae in jirds. It was not microfilaricidal.

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Year:  1979        PMID： 538808     DOI： 10.1016/0035-9203(79)90018-x

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  17 in total

1.  Potential Role for Flubendazole in Limiting Filariasis Transmission: Observations of Microfilarial Sensitivity.

Authors:  Maeghan O'Neill; Jelil Abdel Njouendou; Michael Dzimianski; Erica Burkman; Patrick Chouna Ndongmo; Jonas A Kengne-Ouafo; Samuel Wanji; Andrew Moorhead; Charles D Mackenzie; Timothy G Geary
Journal:  Am J Trop Med Hyg       Date:  2018-01       Impact factor: 2.345

2.  Recent developments in the treatment of onchocerciasis.

Authors:  H R Taylor
Journal:  Bull World Health Organ       Date:  1984       Impact factor: 9.408

3.  Ocular onchocerciasis: current management and future prospects.

Authors:  Olufemi Emmanuel Babalola
Journal:  Clin Ophthalmol       Date:  2011-10-13

4.  Profiling the macrofilaricidal effects of flubendazole on adult female Brugia malayi using RNAseq.

Authors:  Maeghan O'Neill; Cristina Ballesteros; Lucienne Tritten; Erica Burkman; Weam I Zaky; Jianguo Xia; Andrew Moorhead; Steven A Williams; Timothy G Geary
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2016-10-01       Impact factor: 4.077

5.  Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.

Authors:  Hanna T Sjoberg; Nicolas Pionnier; Ghaith Aljayyoussi; Haelly M Metuge; Abdel J Njouendou; Valerine C Chunda; Fanny F Fombad; Dizzle B Tayong; Narcisse V T Gandjui; Desmond N Akumtoh; Patrick W N Chounna; Bertrand L Ndzeshang; Sophie Lachaud; Fetene Tekle; Ludo Quirynen; Marc Engelen; Benny Baeten; Andrew Steven; Stephen A Ward; Mark J Taylor; Samuel Wanji; Joseph D Turner
Journal:  PLoS Negl Trop Dis       Date:  2019-01-16

6.  In vitro flubendazole-induced damage to vital tissues in adult females of the filarial nematode Brugia malayi.

Authors:  Maeghan O'Neill; James F Geary; Dalen W Agnew; Charles D Mackenzie; Timothy G Geary
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2015-07-07       Impact factor: 4.077

7.  An In Vitro/In Vivo Model to Analyze the Effects of Flubendazole Exposure on Adult Female Brugia malayi.

Authors:  Maeghan O'Neill; Abdelmoneim Mansour; Utami DiCosty; James Geary; Michael Dzimianski; Scott D McCall; John W McCall; Charles D Mackenzie; Timothy G Geary
Journal:  PLoS Negl Trop Dis       Date:  2016-05-04

8.  Heterogeneity in the in vitro susceptibility of Loa loa microfilariae to drugs commonly used in parasitological infections.

Authors:  Abdel J Njouendou; Fanny F Fombad; Maeghan O'Neill; Denis Zofou; Chuck Nutting; Patrick C Ndongmo; Arnaud J Kengne-Ouafo; Timothy G Geary; Charles D Mackenzie; Samuel Wanji
Journal:  Parasit Vectors       Date:  2018-04-04       Impact factor: 3.876

9.  Evaluation of oxfendazole in the treatment of zoonotic Onchocerca lupi infection in dogs.

Authors:  Vito Colella; Carla Maia; André Pereira; Nuno Gonçalves; Marta Caruso; Coralie Martin; Luís Cardoso; Lenea Campino; Ivan Scandale; Domenico Otranto
Journal:  PLoS Negl Trop Dis       Date:  2018-01-29

10.  Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.

Authors:  Marc P Hübner; Coralie Martin; Sabine Specht; Marianne Koschel; Bettina Dubben; Stefan J Frohberger; Alexandra Ehrens; Martina Fendler; Dominique Struever; Edward Mitre; Nathaly Vallarino-Lhermitte; Suzanne Gokool; Sara Lustigman; Manfred Schneider; Simon Townson; Achim Hoerauf; Ivan Scandale
Journal:  PLoS Negl Trop Dis       Date:  2020-07-06
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