Literature DB >> 536992

Potential antiinflammatory compounds. 3. Compounds derived from acenaphthene and indan.

C E Smith, W R Williamson, C H Cashin, E A Kitchen.   

Abstract

Compounds having acenaphthene and indan as their parent nuclei were synthesized for antiinflammatory testing. Compounds which showed activity were 1-phenyl-5-acenaphthenylacetic acid and its alpha-methyl derivative (carrageenan rat paw edema) and the same alpha-methylacenaphthenylacetic acid and 2-(4-chlorobenzylidene)-3-oxo-5-indanacetic acid and its alpha-methyl derivative (rat adjuvant arthritis). None of the compounds was more active than the control compounds phenylbutazone and indomethacin.

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Year:  1979        PMID： 536992     DOI： 10.1021/jm00198a007

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  2 in total

1.  Crystal structure of 5''-(4-chloro-benzyl-idene)-4'-(4-chloro-phen-yl)-1'-methyltri-spiro[acenapthylene-1,2'-pyrrolidine-3',1''-cyclo-hexane-3'',2'''-[1,3]dioxane]-2(1H),6''-dione.

Authors:  Kuppan Chandralekha; Deivasigamani Gavaskar; Adukamparai Rajukrishnan Sureshbabu; Srinivasakannan Lakshmi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-10-03

2.  Crystal structure of 5''-benzyl-idene-1'-methyl-4'-phenyl-tri-spiro-[ace-naphthyl-ene-1,2'-pyrrolidine-3',1''-cyclo-hexane-3'',2'''-[1,3]dioxane]-2,6''-dione.

Authors:  Kuppan Chandralekha; Deivasigamani Gavaskar; Adukamparai Rajukrishnan Sureshbabu; Srinivasakannan Lakshmi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-02-20
  2 in total

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