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Literature DB >> 5347695

The eighth component of human complement (C8): isolation, characterization, and hemolytic efficiency.

Abstract

A method was described allowing the isolation of the eighth component of complement, C8, from human serum. C8 is an immunochemically definable, heretofore unrecognized serum protein with a molecular weight of approximately 150,000 and an electrophoretic mobility of a gamma(1)-globulin. It may be obtained with 5% yield as a 5000-fold purified, physicochemically and immunochemically homogeneous protein. Under optimal experimental conditions, a few molecules of C8 were found sufficient for lysis of a cell.

Entities: Disease Species

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Year: 1969 PMID： 5347695 PMCID： PMC2180480 DOI： 10.1084/jem.130.5.1145

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

14 in total

1. Isolation of a thermolabile serum protein which precipitates gamma-globulin aggregates and participates in immune hemolysis.

Authors: H J MULLER-EBERHARD; H G KUNKEL
Journal: Proc Soc Exp Biol Med Date: 1961-02

2. Biologically active water-insoluble protein polymers. I. Their use for isolation of antigens and antibodies.

Authors: S Avrameas; T Ternynck
Journal: J Biol Chem Date: 1967-04-10 Impact factor: 5.157

3. The ninth component of human complement: isolation, description and mode of action.

Authors: U Hadding; H J Müller-Eberhard
Journal: Immunology Date: 1969-06 Impact factor: 7.397

4. The gel-filtration behaviour of proteins related to their molecular weights over a wide range.

Authors: P Andrews
Journal: Biochem J Date: 1965-09 Impact factor: 3.857

5. Efficiency of the first component of complement (C'1) in the hemolytic reaction.

Authors: H R Colten; T Borsos; H J Rapp
Journal: Science Date: 1967-12-22 Impact factor: 47.728

6. The second component of human complement: its isolation, fragmentation by C'1 esterase, and incorporation into C'3 convertase.

Authors: M J Polley; H J Müller-Eberhard
Journal: J Exp Med Date: 1968-09-01 Impact factor: 14.307

5. The chemotactic activity for neutrophil and eosinophil leucocytes of the trimolecular complex of the fifth, sixth and seventh components of human complement (C567) prepared in free solution by the 'reactive lysis' procedure.

Authors: P J Lachmann; A B Kay; R A Thompson
Journal: Immunology Date: 1970-12 Impact factor: 7.397

Review 6. The membrane attack complex.

Authors: H J Müller-Eberhard
Journal: Springer Semin Immunopathol Date: 1984

Review 7. Is the membrane attack complex of complement an enzyme?

Authors: M D Boyle
Journal: Mol Cell Biochem Date: 1984 Impact factor: 3.396

8. Human deficiency of the eighth component of complement. The requirement of C8 for serum Neisseria gonorrhoeae bactericidal activity.

Authors: B H Petersen; J A Graham; G F Brooks
Journal: J Clin Invest Date: 1976-02 Impact factor: 14.808

9. Human platelet-initiated formation and uptake of the C5-9 complex of human complement.

Authors: T S Zimmerman; W P Kolb
Journal: J Clin Invest Date: 1976-01 Impact factor: 14.808

10. Pathogenetic mechanisms in dengue haemorrhagic fever: report of an international collaborative study.

Authors:
Journal: Bull World Health Organ Date: 1973 Impact factor: 9.408

The eighth component of human complement (C8): isolation, characterization, and hemolytic efficiency.

1. Isolation of a thermolabile serum protein which precipitates gamma-globulin aggregates and participates in immune hemolysis.

2. Biologically active water-insoluble protein polymers. I. Their use for isolation of antigens and antibodies.

3. The ninth component of human complement: isolation, description and mode of action.

4. The gel-filtration behaviour of proteins related to their molecular weights over a wide range.

5. Efficiency of the first component of complement (C'1) in the hemolytic reaction.

6. The second component of human complement: its isolation, fragmentation by C'1 esterase, and incorporation into C'3 convertase.

7. Complement: substitution of the terminal component in immune hemolysis by 1,10-phenanthroline.

8. The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement.

9. ISOLATION AND DESCRIPTION OF THE FOURTH COMPONENT OF HUMAN COMPLEMENT.

10. The reaction mechanism of beta-1C-globulin (C'3) in immune hemolysis.

1. Mechanism of complement activation by radiographic contrast media.

Review 2. The complement system: history, pathways, cascade and inhibitors.

3. Activation of human complement by human lymphoid cells sensitized with histocompatibility alloantisera.

4. A new complement-mediated cytolytic mechanism--the C1-bypass activation pathway.