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Literature DB >> 24672678

The complement system: history, pathways, cascade and inhibitors.

Abstract

Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.

Entities: Disease

Keywords: complement activation; complement cascade; complement history; complement inhibitors; complement system

Year: 2012 PMID： 24672678 PMCID： PMC3956958 DOI： 10.1556/EuJMI.2.2012.2.2

Source DB: PubMed Journal: Eur J Microbiol Immunol (Bp) ISSN： 2062-509X

97 in total

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74 in total

Review 1. Complementopathies.

Authors: Andrea C Baines; Robert A Brodsky
Journal: Blood Rev Date: 2017-02-06 Impact factor: 8.250

2. Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia.

Authors: Ainhoa Perez-Diez; Chun-Shu Wong; Xiangdong Liu; Harry Mystakelis; Jian Song; Yong Lu; Virginia Sheikh; Jeffrey S Bourgeois; Andrea Lisco; Elizabeth Laidlaw; Cornelia Cudrici; Chengsong Zhu; Quan-Zhen Li; Alexandra F Freeman; Peter R Williamson; Megan Anderson; Gregg Roby; John S Tsang; Richard Siegel; Irini Sereti
Journal: J Clin Invest Date: 2020-10-01 Impact factor: 14.808

Review 3. Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis.

Authors: Siew-Wai Fong; R Manjunatha Kini; Lisa F P Ng
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4. Complement Factor D protects mice from ethanol-induced inflammation and liver injury.

Authors: Rebecca L McCullough; Megan R McMullen; Megan M Sheehan; Kyle L Poulsen; Sanjoy Roychowdhury; Dian J Chiang; Michele T Pritchard; Juan Caballeria; Laura E Nagy
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Journal: Sci Transl Med Date: 2015-07-22 Impact factor: 17.956