Literature DB >> 5347522

Alpha-naphthoflavone: an inhibitor of hydrocarbon cytotoxicity and microsomal hydroxylase.

L Diamond, H V Gelboin.   

Abstract

Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell cultures and protects the cells against the inhibition of cell multiplication by these carcinogens. Alphla-nalphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells and in liver microsomes from rats previously treated with polycyclic aromatic hydrocarbons, but not in microsomes from control rats.

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Year:  1969        PMID： 5347522     DOI： 10.1126/science.166.3908.1023

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  15 in total

1.  Distribution and inducibility of a P450I activity in cellular components of the avian immune system.

Authors:  N A Lorr; K A Golemboski; R A Hemendinger; R R Dietert; S E Bloom
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

2.  The effect of complete carcinogens on intercellular transfer of lucifer yellow in fibroblast culture.

Authors:  I V Budunova; L A Mittelman; G A Belitsky
Journal:  Cell Biol Toxicol       Date:  1990-01       Impact factor: 6.691

3.  The effect of intracellular oxygen on the metabolization of benzo(a)pyrene and benzo(k)fluoranthene. A microspectrofluorometric analysis in single living cells.

Authors:  J M Salmon; E Kohen; C Kohen; G Bengtsson
Journal:  Histochemistry       Date:  1974

4.  Activation of xenobiotics by monooxygenases: cultures of mammalian cells as analytical tool.

Authors:  F J Wiebel; S Brown; H L Waters; J K Selkirk
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

5.  Selenium modifies carcinogen metabolism by inhibiting enzyme induction.

Authors:  A Dipple; M A Pigott; J A Milner
Journal:  Biol Trace Elem Res       Date:  1986-08       Impact factor: 3.738

6.  Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells.

Authors:  E Huberman; M W Chou; S K Yang
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

7.  Aryl hydrocarbon hydroxylase and polycyclic hydrocarbon tumorigenesis: effect of the enzyme inhibitor 7,8-benzoflavone on tumorigenesis and macromolecule binding.

Authors:  N Kinoshita; H V Gelboin
Journal:  Proc Natl Acad Sci U S A       Date:  1972-04       Impact factor: 11.205

8.  Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium.

Authors:  Yu-Wen Cheng; Ching-Hao Li; Chen-Chen Lee; Jaw-Jou Kang
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-10-15       Impact factor: 3.000

9.  [Tumor prevention by vitamin A: in vitro studies with human cultured fibroblasts (author's transl)].

Authors:  F V Kohl; H W Rüdiger
Journal:  J Cancer Res Clin Oncol       Date:  1979-02-19       Impact factor: 4.553

10.  Acute cytotoxicities of polynuclear aromatic hydrocarbons determined in vitro with the human liver tumor cell line, HepG2.

Authors:  H Babich; M K Sardana; E Borenfreund
Journal:  Cell Biol Toxicol       Date:  1988-09       Impact factor: 6.691
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