Literature DB >> 24254362

Selenium modifies carcinogen metabolism by inhibiting enzyme induction.

A Dipple1, M A Pigott, J A Milner.   

Abstract

Since selenium has been found to exert a protective action against carcinogenesis in various systems, the mechanism where-by sodium selenite inhibits DNA binding of the carcinogen, 7,12-dimethylbenz[a]anthracene, was investigated. It was found that selenite preferentially reduced DNA binding occurring through ananti-dihydrodiol epoxide metabolite of this carcinogen by inhibiting the induction of an enzyme system that generates this specific reactive metabolite.

Entities:  

Year:  1986        PMID： 24254362     DOI： 10.1007/BF02795568

Source DB:  PubMed          Journal:  Biol Trace Elem Res        ISSN： 0163-4984            Impact factor:   3.738


  13 in total

1.  Alpha-naphthoflavone: an inhibitor of hydrocarbon cytotoxicity and microsomal hydroxylase.

Authors:  L Diamond; H V Gelboin
Journal:  Science       Date:  1969-11-21       Impact factor: 47.728

2.  Factors influencing the inhibitory effect of selenium on mice inoculated with Ehrlich ascites tumor cells.

Authors:  G A Greeder; J A Milner
Journal:  Science       Date:  1980-08-15       Impact factor: 47.728

3.  Effect of an inorganic and organic form of dietary selenium on the promotional stage of mammary carcinogenesis in the rat.

Authors:  H J Thompson; L D Meeker; S Kokoska
Journal:  Cancer Res       Date:  1984-07       Impact factor: 12.701

Review 4.  Selenium and cancer: a review.

Authors:  G N Schrauzer
Journal:  Bioinorg Chem       Date:  1976

5.  Acid lability of the hydrocarbon-deoxyribonucleoside linkages in 7,12-dimethylbenz[a]anthracene-modified deoxyribonucleic acid.

Authors:  A Dipple; R C Moschel; M A Pigott; Y Tondeur
Journal:  Biochemistry       Date:  1985-04-23       Impact factor: 3.162

6.  Effect of selenium on virally induced and transplantable tumor models.

Authors:  J A Milner
Journal:  Fed Proc       Date:  1985-06

7.  Selenium concentration and glutathione peroxidase activity in normal and neoplastic development of the mouse mammary gland.

Authors:  H W Lane; D Medina
Journal:  Cancer Res       Date:  1983-04       Impact factor: 12.701

8.  Selenium and mouse mammary tumorigenesis: an investigation of possible mechanisms.

Authors:  D Medina; H W Lane; C M Tracey
Journal:  Cancer Res       Date:  1983-05       Impact factor: 12.701

9.  Involvement of both syn- and anti-dihydrodiol-epoxides in the binding of 7, 12-dimethylbenz(a)anthracene to DNA in mouse embryo cell cultures.

Authors:  J T Sawicki; R C Moschel; A Dipple
Journal:  Cancer Res       Date:  1983-07       Impact factor: 12.701

Review 10.  Toxicology of selenium: a review.

Authors:  C G Wilber
Journal:  Clin Toxicol       Date:  1980-09       Impact factor: 4.467
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  2 in total

1.  Systematic study of the selenium fractionation in human plasma from a cancer prevention trial using HPLC hyphenated to ICP-MS and ESI-MS/MS.

Authors:  Christian L Ward-Deitrich; Emily Whyte; Christopher Hopley; Margaret P Rayman; Yasumitsu Ogra; Heidi Goenaga-Infante
Journal:  Anal Bioanal Chem       Date:  2020-11-02       Impact factor: 4.142

2.  Chemoprevention of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in rat by the combined actions of selenium, magnesium, ascorbic acid and retinyl acetate.

Authors:  A Ramesha; N Rao; A R Rao; L N Jannu; S P Hussain
Journal:  Jpn J Cancer Res       Date:  1990-12
  2 in total

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