Literature DB >> 5341602

Phenotype masking and streptomycin dependence.

L Gorini, R Rosset, R A Zimmermann.   

Abstract

In attempting to define the role of ribosomes in the mechanism of streptomycin dependence, a new phenomenon has been discovered. Analysis of this phenomenon-called phenotypic masking-leads to the conclusion that "streptomycin dependent" mutants are actually "drug dependent" because their dependence is equally satisfied by several drugs. These drugs, some of which are totally unrelated chemically, act on the ribosome and induce misreading in vitro and suppression in vivo.

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Year:  1967        PMID： 5341602     DOI： 10.1126/science.157.3794.1314

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

Review 1.  The parable of the caveman and the Ferrari: protein synthesis and the RNA world.

Authors:  Harry F Noller
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2017-03-19       Impact factor: 6.237

2.  Altered surface properties of Escherichia coli associated with a specific amino acid change in the S12 ribosomal protein of streptomycin-resistant mutants.

Authors:  S Pestka; H Walter; L G Wayne
Journal:  Antimicrob Agents Chemother       Date:  1977-06       Impact factor: 5.191

3.  Genetic characterization of streptomycin-resistant and -dependent mutants of Escherichia coli K12.

Authors:  F J Sánchez-Anzaldo; F Bastarrachea
Journal:  Mol Gen Genet       Date:  1974-04-09

4.  Organic solvents as probes for the structure and function of the bacterial membrane: effects of ethanol on the wild type and an ethanol-resistant mutant of Escherichia coli K-12.

Authors:  V A Fried; A Novick
Journal:  J Bacteriol       Date:  1973-04       Impact factor: 3.490

5.  Ribosomal assembly influenced by growth in the presence of streptomycin.

Authors:  R T Garvin; R Rosset; L Gorini
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

6.  The attachment site of streptomycin to the 30S ribosomal subunit.

Authors:  D K Biswas; L Gorini
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

7.  The effects of streptomycin or dihydrostreptomycin binding to 16S RNA or to 30S ribosomal subunits.

Authors:  R T Garvin; D K Biswas; L Gorini
Journal:  Proc Natl Acad Sci U S A       Date:  1974-10       Impact factor: 11.205

8.  Antibiotic inhibitors of the bacterial ribosome.

Authors:  B Weisblum; J Davies
Journal:  Bacteriol Rev       Date:  1968-12

9.  Coresistance to neomycin and kanamycin by mutations in an Escherichia coli locus that affects ribosomes.

Authors:  D Apirion; D Schlessinger
Journal:  J Bacteriol       Date:  1968-09       Impact factor: 3.490

10.  Mutation to erythromycin dependence in Escherichia coli K-12.

Authors:  P F Sparling; E Blackman
Journal:  J Bacteriol       Date:  1973-10       Impact factor: 3.490
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