Literature DB >> 4139702

The effects of streptomycin or dihydrostreptomycin binding to 16S RNA or to 30S ribosomal subunits.

R T Garvin, D K Biswas, L Gorini.   

Abstract

Evidence is presented suggesting that streptomycin binds to 16S RNA or to 30S ribosomal subunits at the same topographical site located on the RNA chain. The equally bactericidal dihydrostreptomycin binds to the same site as streptomycin but with lower affinity. The effect of drug binding to 16S RNA (measured by reconstitution inhibition) is readily reversible, while that of drug binding to 30S subunits (measured by misreading) persists after removal of the drug. Binding of the drug is not a necessary and sufficient reason for killing.

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Year:  1974        PMID： 4139702      PMCID： PMC434274          DOI： 10.1073/pnas.71.10.3814

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Ribosomal assembly influenced by growth in the presence of streptomycin.

Authors:  R T Garvin; R Rosset; L Gorini
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

2.  The attachment site of streptomycin to the 30S ribosomal subunit.

Authors:  D K Biswas; L Gorini
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

3.  Binding of dihydrostreptomycin to ribosomal subunits.

Authors:  H Kaji; Y Tanaka
Journal:  J Mol Biol       Date:  1968-03-14       Impact factor: 5.469

4.  Identification and functional characterization of the protein controlled by the streptomycin-resistant locus in E. coli.

Authors:  M Ozaki; S Mizushima; M Nomura
Journal:  Nature       Date:  1969-04-26       Impact factor: 49.962

5.  Nature of phenotypic masking exhibited by drug-dependent streptomycin A mutants of Escherichia coli.

Authors:  R A Zimmermann; R Rosset; L Gorini
Journal:  J Mol Biol       Date:  1971-05-14       Impact factor: 5.469

6.  A ribosomal ambiguity mutation.

Authors:  R Rosset; L Gorini
Journal:  J Mol Biol       Date:  1969-01-14       Impact factor: 5.469

7.  Genetic analysis of streptomycin resistance in Escherichia coli.

Authors:  L Breckenridge; L Gorini
Journal:  Genetics       Date:  1970-05       Impact factor: 4.562

8.  Phenotype masking and streptomycin dependence.

Authors:  L Gorini; R Rosset; R A Zimmermann
Journal:  Science       Date:  1967-09-15       Impact factor: 47.728

9.  Thin layer chromatography (bioautography) of streptomycins.

Authors:  H Heding
Journal:  Acta Chem Scand       Date:  1970

10.  Alteration of a 30S ribosomal protein accompanying the ram mutation in Escherichia coli.

Authors:  R A Zimmermann; R T Garvin; L Gorini
Journal:  Proc Natl Acad Sci U S A       Date:  1971-09       Impact factor: 11.205
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  13 in total

Review 1.  Office of Naval Research lecture. Antibiotics and the search for new principles.

Authors:  E Cundliffe
Journal:  J Ind Microbiol       Date:  1991-04

2.  Mutations in the 915 region of Escherichia coli 16S ribosomal RNA reduce the binding of streptomycin to the ribosome.

Authors:  D Leclerc; P Melançon; L Brakier-Gingras
Journal:  Nucleic Acids Res       Date:  1991-07-25       Impact factor: 16.971

3.  A ribonucleoprotein precursor of both the 30S and 50S ribosomal sunbunits of Escherichia coli.

Authors:  M J Duncan; L Gorini
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

4.  Mechanisms of streptomycin resistance: selection of mutations in the 16S rRNA gene conferring resistance.

Authors:  B Springer; Y G Kidan; T Prammananan; K Ellrott; E C Böttger; P Sander
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

5.  On the basis of aminoglycoside-dependent growth of mutants of Escherichia coli: in vitro studies and the model.

Authors:  H Hummel; M H Ahmad; A Böck
Journal:  Mol Gen Genet       Date:  1983

6.  On the basis of aminoglycoside-dependent growth of mutants from E. coli: physiological studies.

Authors:  H Hummel; A Böck
Journal:  Mol Gen Genet       Date:  1983

7.  Identification of components of the streptomycin-binding center of E. coli MRE 600 ribosomes by photo-affinity labelling.

Authors:  A S Girshovich; E S Bochkareva; Y A Ovchinnikov
Journal:  Mol Gen Genet       Date:  1976-03-22

8.  Ribosomal protein S12 and aminoglycoside antibiotics modulate A-site mRNA cleavage and transfer-messenger RNA activity in Escherichia coli.

Authors:  Laura E Holberger; Christopher S Hayes
Journal:  J Biol Chem       Date:  2009-09-23       Impact factor: 5.157

9.  [3H] dihydrostreptomycin accumulation and binding to ribosomes in Rhizobium mutants with different levels of streptomycin resistance.

Authors:  I Zelazna-Kowalska
Journal:  J Bacteriol       Date:  1977-10       Impact factor: 3.490

10.  A functional pseudoknot in 16S ribosomal RNA.

Authors:  T Powers; H F Noller
Journal:  EMBO J       Date:  1991-08       Impact factor: 11.598
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