Antibody responses to and efficacy of an inactivated spray vaccine.

An attempt was made to assess the protective influence of killed intranasal influenza B vaccine against a homologous virus challenge. Two types of trial were performed. In the first of these, the vaccine was compared with an inert placebo and, in the second, with conventional homologous and heterologous parenteral vaccines. Little protective effect by the intranasal vaccine was demonstrated.

RCT Entities:   Population Interventions Outcomes